Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study

Cunxian Shi,* Jin Jin,* Leyan Qiao, Tao Li, Jiahai Ma, Zhikun Ma Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China*These authors contributed equally to this workObjective: Postoperative delirium (POD) is a serious complicat...

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Autores principales:	Shi CX, Jin J, Qiao LY, Li T, Ma JH, Ma ZK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	dexmedetomidine perioperative sedation delirium cardiac surgery elderly patients. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/751861885c0c427da257a18db7fd4946
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spelling	oai:doaj.org-article:751861885c0c427da257a18db7fd49462021-12-02T06:21:45ZEffect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study1178-1998https://doaj.org/article/751861885c0c427da257a18db7fd49462019-03-01T00:00:00Zhttps://www.dovepress.com/effect-of-perioperative-administration-of-dexmedetomidine-on-delirium--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Cunxian Shi,* Jin Jin,* Leyan Qiao, Tao Li, Jiahai Ma, Zhikun Ma Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China*These authors contributed equally to this workObjective: Postoperative delirium (POD) is a serious complication in elderly patients undergoing cardiac surgery. This study was aimed at investigating the effect of perioperative administration of dexmedetomidine for general anesthesia maintenance on occurrence and duration of POD in elderly patients after cardiac surgery.Methods: One hundred and sixty-four patients were enrolled after cardiac surgery between June 2009 and December 2016. Patients were assigned by a computer-generated randomization sequence in a 1:1 ratio to receive dexmedetomidine general anesthesia maintenance or propofol general anesthesia maintenance. POD was assessed every day with confusion assessment method for intensive care units (ICU) during the first 5 postoperative days.Results: There was no significance in incidence of POD between the dexmedetomidine group and the propofol group (P=0.0758). In patients treated with dexmedetomidine, the median onset time of delirium was delayed (second day vs first day) and the duration of delirium reduced (2 days vs 3 days) when compared with propofol-treated patients. The dexmedetomidine-treated patients also displayed a lower VAS score and less opiate analgesic consumption. No difference was observed in respect to other postoperative outcomes.Conclusion: For elderly patients, perioperative administration of dexmedetomidine reduced incidence, delayed onset and shortened duration of POD after cardiac surgery.Keywords: dexmedetomidine, postoperative delirium, anesthesia, cardiac surgery, elderly patientsShi CXJin JQiao LYLi TMa JHMa ZKDove Medical Pressarticledexmedetomidineperioperative sedationdeliriumcardiac surgeryelderly patients.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 571-575 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dexmedetomidine perioperative sedation delirium cardiac surgery elderly patients. Geriatrics RC952-954.6
spellingShingle	dexmedetomidine perioperative sedation delirium cardiac surgery elderly patients. Geriatrics RC952-954.6 Shi CX Jin J Qiao LY Li T Ma JH Ma ZK Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
description	Cunxian Shi,* Jin Jin,* Leyan Qiao, Tao Li, Jiahai Ma, Zhikun Ma Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China*These authors contributed equally to this workObjective: Postoperative delirium (POD) is a serious complication in elderly patients undergoing cardiac surgery. This study was aimed at investigating the effect of perioperative administration of dexmedetomidine for general anesthesia maintenance on occurrence and duration of POD in elderly patients after cardiac surgery.Methods: One hundred and sixty-four patients were enrolled after cardiac surgery between June 2009 and December 2016. Patients were assigned by a computer-generated randomization sequence in a 1:1 ratio to receive dexmedetomidine general anesthesia maintenance or propofol general anesthesia maintenance. POD was assessed every day with confusion assessment method for intensive care units (ICU) during the first 5 postoperative days.Results: There was no significance in incidence of POD between the dexmedetomidine group and the propofol group (P=0.0758). In patients treated with dexmedetomidine, the median onset time of delirium was delayed (second day vs first day) and the duration of delirium reduced (2 days vs 3 days) when compared with propofol-treated patients. The dexmedetomidine-treated patients also displayed a lower VAS score and less opiate analgesic consumption. No difference was observed in respect to other postoperative outcomes.Conclusion: For elderly patients, perioperative administration of dexmedetomidine reduced incidence, delayed onset and shortened duration of POD after cardiac surgery.Keywords: dexmedetomidine, postoperative delirium, anesthesia, cardiac surgery, elderly patients
format	article
author	Shi CX Jin J Qiao LY Li T Ma JH Ma ZK
author_facet	Shi CX Jin J Qiao LY Li T Ma JH Ma ZK
author_sort	Shi CX
title	Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
title_short	Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
title_full	Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
title_fullStr	Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
title_full_unstemmed	Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
title_sort	effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/751861885c0c427da257a18db7fd4946
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Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study

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