Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacological inhibition of KDM3A attenuates cardiac remode...

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Autores principales:	Qing-Jun Zhang, Tram Anh T. Tran, Ming Wang, Mark J. Ranek, Kristen M. Kokkonen-Simon, Jason Gao, Xiang Luo, Wei Tan, Viktoriia Kyrychenko, Lan Liao, Jianming Xu, Joseph A. Hill, Eric N. Olson, David A. Kass, Elisabeth D. Martinez, Zhi-Ping Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7518fe10d5ab4b61a96ce3487b11c73b
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spelling	oai:doaj.org-article:7518fe10d5ab4b61a96ce3487b11c73b2021-12-02T16:49:31ZHistone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis10.1038/s41467-018-07173-22041-1723https://doaj.org/article/7518fe10d5ab4b61a96ce3487b11c73b2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07173-2https://doaj.org/toc/2041-1723Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacological inhibition of KDM3A attenuates cardiac remodeling induced by pressure overload.Qing-Jun ZhangTram Anh T. TranMing WangMark J. RanekKristen M. Kokkonen-SimonJason GaoXiang LuoWei TanViktoriia KyrychenkoLan LiaoJianming XuJoseph A. HillEric N. OlsonDavid A. KassElisabeth D. MartinezZhi-Ping LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing-Jun Zhang Tram Anh T. Tran Ming Wang Mark J. Ranek Kristen M. Kokkonen-Simon Jason Gao Xiang Luo Wei Tan Viktoriia Kyrychenko Lan Liao Jianming Xu Joseph A. Hill Eric N. Olson David A. Kass Elisabeth D. Martinez Zhi-Ping Liu Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
description	Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacological inhibition of KDM3A attenuates cardiac remodeling induced by pressure overload.
format	article
author	Qing-Jun Zhang Tram Anh T. Tran Ming Wang Mark J. Ranek Kristen M. Kokkonen-Simon Jason Gao Xiang Luo Wei Tan Viktoriia Kyrychenko Lan Liao Jianming Xu Joseph A. Hill Eric N. Olson David A. Kass Elisabeth D. Martinez Zhi-Ping Liu
author_facet	Qing-Jun Zhang Tram Anh T. Tran Ming Wang Mark J. Ranek Kristen M. Kokkonen-Simon Jason Gao Xiang Luo Wei Tan Viktoriia Kyrychenko Lan Liao Jianming Xu Joseph A. Hill Eric N. Olson David A. Kass Elisabeth D. Martinez Zhi-Ping Liu
author_sort	Qing-Jun Zhang
title	Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
title_short	Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
title_full	Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
title_fullStr	Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
title_full_unstemmed	Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
title_sort	histone lysine dimethyl-demethylase kdm3a controls pathological cardiac hypertrophy and fibrosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7518fe10d5ab4b61a96ce3487b11c73b
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Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

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