Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
Histone lysine demethylases (KDMs) can mediate transcriptional reprogramming in disease states. Here the authors show that KDM3A promotes left ventricular hypertrophy and cardiac fibrosis by activating the transcription of Timp1, and that pharmacological inhibition of KDM3A attenuates cardiac remode...
Guardado en:
Autores principales: | Qing-Jun Zhang, Tram Anh T. Tran, Ming Wang, Mark J. Ranek, Kristen M. Kokkonen-Simon, Jason Gao, Xiang Luo, Wei Tan, Viktoriia Kyrychenko, Lan Liao, Jianming Xu, Joseph A. Hill, Eric N. Olson, David A. Kass, Elisabeth D. Martinez, Zhi-Ping Liu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/7518fe10d5ab4b61a96ce3487b11c73b |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner.
por: Kristine Williams, et al.
Publicado: (2014) -
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling
por: James E. Longbotham, et al.
Publicado: (2019) -
Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
por: Louise J. Walport, et al.
Publicado: (2016) -
Interplay between Prokineticins and Histone Demethylase KDM6A in a Murine Model of Bortezomib-Induced Neuropathy
por: Laura Rullo, et al.
Publicado: (2021) -
Polycomb represses a gene network controlling puberty via modulation of histone demethylase Kdm6b expression
por: Hollis Wright, et al.
Publicado: (2021)