Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?

Susan J Lee1, Augusto Paranhos2, M Bruce Shields11Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Federal University of S&atilde;o Paulo, S&atilde;o Paulo, BrazilPurpose: To evaluate the benefit of titrating the concen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Susan J Lee, Augusto Paranhos, M Bruce Shields
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/751982a5d1e645788260b26c0f816b20
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:751982a5d1e645788260b26c0f816b20
record_format	dspace
spelling	oai:doaj.org-article:751982a5d1e645788260b26c0f816b202021-12-02T01:49:49ZDoes titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?1177-54671177-5483https://doaj.org/article/751982a5d1e645788260b26c0f816b202008-09-01T00:00:00Zhttp://www.dovepress.com/does-titration-of-mitomycin-c-as-an-adjunct-to-trabeculectomy-signific-a2270https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Susan J Lee1, Augusto Paranhos2, M Bruce Shields11Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Federal University of S&atilde;o Paulo, S&atilde;o Paulo, BrazilPurpose: To evaluate the benefit of titrating the concentration and exposure time of mitomycin C (MMC) as an adjunct to trabeculectomy.Methods: This report consists of a retrospective study and a review of the literature. In the study, consecutive glaucoma patients were evaluated who underwent trabeculectomy with adjunctive MMC that was titrated for concentration and exposure time, based on patient&rsquo;s risk factors for surgical failure. After minimum follow-up of 6 months, patients were divided into success (intraocular pressure 7&ndash;17 mmHg), hypertension (&gt;17 mmHg) and hypotony (&lt;7 mmHg) groups, which were compared with regard to MMC protocol and patient variables. The literature review included reports of trabeculectomy and adjunctive MMC with and without titration.Results: One hundred and fifty-five eyes of 155 patients were studied. There were no significant differences between the three outcome groups and MMC protocol (p &gt; 0.05). The only significant patient variable was older age in the hypotony group (p = 0.009). The literature is conflicting regarding the value of titrating MMC as an adjunct in trabeculectomy.Conclusion: The outcome of trabeculectomy with adjunctive MMC appears to represent a complex interaction of patient and surgical variables. While there is some support for a benefit of titrating MMC according to individual patient variables, there is inadequate evidence at the present time to claim superiority for any MMC protocol, with or without titration.Keywords: glaucoma surgery, trabeculectomy, mitomycin C, intraocular pressure Susan J LeeAugusto ParanhosM Bruce ShieldsDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 81-87 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Susan J Lee Augusto Paranhos M Bruce Shields Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
description	Susan J Lee1, Augusto Paranhos2, M Bruce Shields11Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Federal University of S&atilde;o Paulo, S&atilde;o Paulo, BrazilPurpose: To evaluate the benefit of titrating the concentration and exposure time of mitomycin C (MMC) as an adjunct to trabeculectomy.Methods: This report consists of a retrospective study and a review of the literature. In the study, consecutive glaucoma patients were evaluated who underwent trabeculectomy with adjunctive MMC that was titrated for concentration and exposure time, based on patient&rsquo;s risk factors for surgical failure. After minimum follow-up of 6 months, patients were divided into success (intraocular pressure 7&ndash;17 mmHg), hypertension (&gt;17 mmHg) and hypotony (&lt;7 mmHg) groups, which were compared with regard to MMC protocol and patient variables. The literature review included reports of trabeculectomy and adjunctive MMC with and without titration.Results: One hundred and fifty-five eyes of 155 patients were studied. There were no significant differences between the three outcome groups and MMC protocol (p &gt; 0.05). The only significant patient variable was older age in the hypotony group (p = 0.009). The literature is conflicting regarding the value of titrating MMC as an adjunct in trabeculectomy.Conclusion: The outcome of trabeculectomy with adjunctive MMC appears to represent a complex interaction of patient and surgical variables. While there is some support for a benefit of titrating MMC according to individual patient variables, there is inadequate evidence at the present time to claim superiority for any MMC protocol, with or without titration.Keywords: glaucoma surgery, trabeculectomy, mitomycin C, intraocular pressure
format	article
author	Susan J Lee Augusto Paranhos M Bruce Shields
author_facet	Susan J Lee Augusto Paranhos M Bruce Shields
author_sort	Susan J Lee
title	Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
title_short	Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
title_full	Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
title_fullStr	Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
title_full_unstemmed	Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
title_sort	does titration of mitomycin c as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/751982a5d1e645788260b26c0f816b20
work_keys_str_mv	AT susanjlee doestitrationofmitomycincasanadjuncttotrabeculectomysignificantlyinfluencetheintraocularpressureoutcome AT augustoparanhos doestitrationofmitomycincasanadjuncttotrabeculectomysignificantlyinfluencetheintraocularpressureoutcome AT mbruceshields doestitrationofmitomycincasanadjuncttotrabeculectomysignificantlyinfluencetheintraocularpressureoutcome
_version_	1718402846571888640

Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?

Ejemplares similares