The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis

Phospholipase ExoU from Pseudomonas aeruginosa acts on plasma membrane lipids in infected cells, causing membrane rupture and host cell necrosis. Here, Deruelle et al. show that once injected into the host cytoplasm, ExoU requires a host chaperone found on secretory vesicles to reach the plasma memb...

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Autores principales:	Vincent Deruelle, Stéphanie Bouillot, Viviana Job, Emmanuel Taillebourg, Marie-Odile Fauvarque, Ina Attrée, Philippe Huber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7519ae424bed4a3fa20bea268022baf3
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spelling	oai:doaj.org-article:7519ae424bed4a3fa20bea268022baf32021-12-02T18:18:36ZThe bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis10.1038/s41467-021-24337-92041-1723https://doaj.org/article/7519ae424bed4a3fa20bea268022baf32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24337-9https://doaj.org/toc/2041-1723Phospholipase ExoU from Pseudomonas aeruginosa acts on plasma membrane lipids in infected cells, causing membrane rupture and host cell necrosis. Here, Deruelle et al. show that once injected into the host cytoplasm, ExoU requires a host chaperone found on secretory vesicles to reach the plasma membrane and exerts its phospholipase activity.Vincent DeruelleStéphanie BouillotViviana JobEmmanuel TaillebourgMarie-Odile FauvarqueIna AttréePhilippe HuberNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vincent Deruelle Stéphanie Bouillot Viviana Job Emmanuel Taillebourg Marie-Odile Fauvarque Ina Attrée Philippe Huber The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
description	Phospholipase ExoU from Pseudomonas aeruginosa acts on plasma membrane lipids in infected cells, causing membrane rupture and host cell necrosis. Here, Deruelle et al. show that once injected into the host cytoplasm, ExoU requires a host chaperone found on secretory vesicles to reach the plasma membrane and exerts its phospholipase activity.
format	article
author	Vincent Deruelle Stéphanie Bouillot Viviana Job Emmanuel Taillebourg Marie-Odile Fauvarque Ina Attrée Philippe Huber
author_facet	Vincent Deruelle Stéphanie Bouillot Viviana Job Emmanuel Taillebourg Marie-Odile Fauvarque Ina Attrée Philippe Huber
author_sort	Vincent Deruelle
title	The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
title_short	The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
title_full	The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
title_fullStr	The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
title_full_unstemmed	The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
title_sort	bacterial toxin exou requires a host trafficking chaperone for transportation and to induce necrosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7519ae424bed4a3fa20bea268022baf3
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The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis

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