Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.

Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.

HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor on target T-cells. Understanding how these ligands influence the structure of Env is of fundamental interest for HIV vaccine development. Using cryo-electron microscopy, we describe the co...

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Detalles Bibliográficos
Autores principales: Erin E H Tran, Mario J Borgnia, Oleg Kuybeda, David M Schauder, Alberto Bartesaghi, Gabriel A Frank, Guillermo Sapiro, Jacqueline L S Milne, Sriram Subramaniam
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/751ac1f8702e4987964ef6137c268483
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