Rational design of universal immunotherapy for TfR1-tropic arenaviruses

New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against pathogenic mammarenaviruses.

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Autores principales:	Hadas Cohen-Dvashi, Ron Amon, Krystle N. Agans, Robert W. Cross, Aliza Borenstein-Katz, Mathieu Mateo, Sylvain Baize, Vered Padler-Karavani, Thomas W. Geisbert, Ron Diskin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/751b79cf93674fd5a0d73e4333ca7172
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spelling	oai:doaj.org-article:751b79cf93674fd5a0d73e4333ca71722021-12-02T15:39:19ZRational design of universal immunotherapy for TfR1-tropic arenaviruses10.1038/s41467-019-13924-62041-1723https://doaj.org/article/751b79cf93674fd5a0d73e4333ca71722020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13924-6https://doaj.org/toc/2041-1723New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against pathogenic mammarenaviruses.Hadas Cohen-DvashiRon AmonKrystle N. AgansRobert W. CrossAliza Borenstein-KatzMathieu MateoSylvain BaizeVered Padler-KaravaniThomas W. GeisbertRon DiskinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hadas Cohen-Dvashi Ron Amon Krystle N. Agans Robert W. Cross Aliza Borenstein-Katz Mathieu Mateo Sylvain Baize Vered Padler-Karavani Thomas W. Geisbert Ron Diskin Rational design of universal immunotherapy for TfR1-tropic arenaviruses
description	New World arenaviruses utilize the cellular transferrin receptor 1 (TfR1) to enter host cells. Here, the authors develop a TfR1-mimetic immunoadhesin, Arenacept, that targets viral spike complexes and exerts effective pan-reactive neutralization against pathogenic mammarenaviruses.
format	article
author	Hadas Cohen-Dvashi Ron Amon Krystle N. Agans Robert W. Cross Aliza Borenstein-Katz Mathieu Mateo Sylvain Baize Vered Padler-Karavani Thomas W. Geisbert Ron Diskin
author_facet	Hadas Cohen-Dvashi Ron Amon Krystle N. Agans Robert W. Cross Aliza Borenstein-Katz Mathieu Mateo Sylvain Baize Vered Padler-Karavani Thomas W. Geisbert Ron Diskin
author_sort	Hadas Cohen-Dvashi
title	Rational design of universal immunotherapy for TfR1-tropic arenaviruses
title_short	Rational design of universal immunotherapy for TfR1-tropic arenaviruses
title_full	Rational design of universal immunotherapy for TfR1-tropic arenaviruses
title_fullStr	Rational design of universal immunotherapy for TfR1-tropic arenaviruses
title_full_unstemmed	Rational design of universal immunotherapy for TfR1-tropic arenaviruses
title_sort	rational design of universal immunotherapy for tfr1-tropic arenaviruses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/751b79cf93674fd5a0d73e4333ca7172
work_keys_str_mv	AT hadascohendvashi rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT ronamon rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT krystlenagans rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT robertwcross rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT alizaborensteinkatz rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT mathieumateo rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT sylvainbaize rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT veredpadlerkaravani rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT thomaswgeisbert rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses AT rondiskin rationaldesignofuniversalimmunotherapyfortfr1tropicarenaviruses
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Rational design of universal immunotherapy for TfR1-tropic arenaviruses

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