The ambiguous role of mannose-binding lectin (MBL) in human immunity

Mannose-binding lectin (MBL) and lectin complement pathway have become targets of increasing clinical interest. Many aspects of MBL have been recently explored, including the structural properties that allow it to distinguish self from non-self/altered-self structures. Experimental evidences have de...

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Autores principales:	Kalia Namarta, Singh Jatinder, Kaur Manpreet
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	infectious diseases autoimmune diseases single nucleotide polymorphisms functional snps 5′ near gene 3′utr variants phagocytosis and mbl patents Medicine R
Acceso en línea:	https://doaj.org/article/751cbc5a79354ae39f1271575d56a4a3
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spelling	oai:doaj.org-article:751cbc5a79354ae39f1271575d56a4a32021-12-05T14:10:54ZThe ambiguous role of mannose-binding lectin (MBL) in human immunity2391-546310.1515/med-2021-0239https://doaj.org/article/751cbc5a79354ae39f1271575d56a4a32021-02-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0239https://doaj.org/toc/2391-5463Mannose-binding lectin (MBL) and lectin complement pathway have become targets of increasing clinical interest. Many aspects of MBL have been recently explored, including the structural properties that allow it to distinguish self from non-self/altered-self structures. Experimental evidences have declared the additional 5′- and 3′-variants that in amalgamation with well-known secretor polymorphisms change MBL function and concentration. Moreover, the current review highlights the differential behavior of MBL on exposure with extra/intracellular pathogens and in autoimmune diseases, stressing the fact that “high MBL levels can increase diseases susceptibility,” a paradox that needs justification. Attributable to these discrepancies, no absolute level of MBL deficiency could be defined so far and thus must be interpreted for specific diseases through case–control population-specific designs. Overall, it is evident that further research is needed about MBL and the lectin pathway of complement. Particularly, the transformative role of MBL over evolution is of interest and its role with regard to pathogenesis of different diseases and potential therapeutic targets within the respective pathways should be further explored. Apart from this, it is necessary to adopt an extensive locus-wide methodology to apprehend the clinical significance of MBL2 polymorphisms in a variety of infectious diseases by the future studies.Kalia NamartaSingh JatinderKaur ManpreetDe Gruyterarticleinfectious diseasesautoimmune diseasessingle nucleotide polymorphismsfunctional snps5′ near gene3′utrvariantsphagocytosis and mbl patentsMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 299-310 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	infectious diseases autoimmune diseases single nucleotide polymorphisms functional snps 5′ near gene 3′utr variants phagocytosis and mbl patents Medicine R
spellingShingle	infectious diseases autoimmune diseases single nucleotide polymorphisms functional snps 5′ near gene 3′utr variants phagocytosis and mbl patents Medicine R Kalia Namarta Singh Jatinder Kaur Manpreet The ambiguous role of mannose-binding lectin (MBL) in human immunity
description	Mannose-binding lectin (MBL) and lectin complement pathway have become targets of increasing clinical interest. Many aspects of MBL have been recently explored, including the structural properties that allow it to distinguish self from non-self/altered-self structures. Experimental evidences have declared the additional 5′- and 3′-variants that in amalgamation with well-known secretor polymorphisms change MBL function and concentration. Moreover, the current review highlights the differential behavior of MBL on exposure with extra/intracellular pathogens and in autoimmune diseases, stressing the fact that “high MBL levels can increase diseases susceptibility,” a paradox that needs justification. Attributable to these discrepancies, no absolute level of MBL deficiency could be defined so far and thus must be interpreted for specific diseases through case–control population-specific designs. Overall, it is evident that further research is needed about MBL and the lectin pathway of complement. Particularly, the transformative role of MBL over evolution is of interest and its role with regard to pathogenesis of different diseases and potential therapeutic targets within the respective pathways should be further explored. Apart from this, it is necessary to adopt an extensive locus-wide methodology to apprehend the clinical significance of MBL2 polymorphisms in a variety of infectious diseases by the future studies.
format	article
author	Kalia Namarta Singh Jatinder Kaur Manpreet
author_facet	Kalia Namarta Singh Jatinder Kaur Manpreet
author_sort	Kalia Namarta
title	The ambiguous role of mannose-binding lectin (MBL) in human immunity
title_short	The ambiguous role of mannose-binding lectin (MBL) in human immunity
title_full	The ambiguous role of mannose-binding lectin (MBL) in human immunity
title_fullStr	The ambiguous role of mannose-binding lectin (MBL) in human immunity
title_full_unstemmed	The ambiguous role of mannose-binding lectin (MBL) in human immunity
title_sort	ambiguous role of mannose-binding lectin (mbl) in human immunity
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/751cbc5a79354ae39f1271575d56a4a3
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The ambiguous role of mannose-binding lectin (MBL) in human immunity

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