Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.
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Nature Portfolio
2019
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oai:doaj.org-article:751f4dad2db84b0f893ba0445a18b1bd2021-12-02T16:57:24ZMitogenic and progenitor gene programmes in single pilocytic astrocytoma cells10.1038/s41467-019-11493-22041-1723https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11493-2https://doaj.org/toc/2041-1723Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically.Zachary J. ReitmanBrenton R. PaolellaGuillaume BergtholdKristine PeltonSarah BeckerRobert JonesClaire E. SinaiHayley MalkinYing HuangLeslie GrimmetZachary T. HerbertYu SunJessica L. WeatherbeeJohn A. AlbertaJohn F. DaleyOrit Rozenblatt-RosenAlexandra L. ConduratKenin QianPrasidda KhadkaRosalind A. SegalDaphne Haas-KoganMariella G. FilbinMario L. SuvaAviv RegevCharles D. StilesMark W. KieranLiliana GoumnerovaKeith L. LigonAlex K. ShalekPratiti BandopadhayayRameen BeroukhimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zachary J. Reitman Brenton R. Paolella Guillaume Bergthold Kristine Pelton Sarah Becker Robert Jones Claire E. Sinai Hayley Malkin Ying Huang Leslie Grimmet Zachary T. Herbert Yu Sun Jessica L. Weatherbee John A. Alberta John F. Daley Orit Rozenblatt-Rosen Alexandra L. Condurat Kenin Qian Prasidda Khadka Rosalind A. Segal Daphne Haas-Kogan Mariella G. Filbin Mario L. Suva Aviv Regev Charles D. Stiles Mark W. Kieran Liliana Goumnerova Keith L. Ligon Alex K. Shalek Pratiti Bandopadhayay Rameen Beroukhim Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| description |
Pilocytic astrocytoma is a low-grade pediatric glioma, characterized by a single BRAF rearrangement. Here, Reitman and colleagues use single-cell RNA sequencing to reveal molecular hallmarks of the disease that might be targeted therapeutically. |
| format |
article |
| author |
Zachary J. Reitman Brenton R. Paolella Guillaume Bergthold Kristine Pelton Sarah Becker Robert Jones Claire E. Sinai Hayley Malkin Ying Huang Leslie Grimmet Zachary T. Herbert Yu Sun Jessica L. Weatherbee John A. Alberta John F. Daley Orit Rozenblatt-Rosen Alexandra L. Condurat Kenin Qian Prasidda Khadka Rosalind A. Segal Daphne Haas-Kogan Mariella G. Filbin Mario L. Suva Aviv Regev Charles D. Stiles Mark W. Kieran Liliana Goumnerova Keith L. Ligon Alex K. Shalek Pratiti Bandopadhayay Rameen Beroukhim |
| author_facet |
Zachary J. Reitman Brenton R. Paolella Guillaume Bergthold Kristine Pelton Sarah Becker Robert Jones Claire E. Sinai Hayley Malkin Ying Huang Leslie Grimmet Zachary T. Herbert Yu Sun Jessica L. Weatherbee John A. Alberta John F. Daley Orit Rozenblatt-Rosen Alexandra L. Condurat Kenin Qian Prasidda Khadka Rosalind A. Segal Daphne Haas-Kogan Mariella G. Filbin Mario L. Suva Aviv Regev Charles D. Stiles Mark W. Kieran Liliana Goumnerova Keith L. Ligon Alex K. Shalek Pratiti Bandopadhayay Rameen Beroukhim |
| author_sort |
Zachary J. Reitman |
| title |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| title_short |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| title_full |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| title_fullStr |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| title_full_unstemmed |
Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| title_sort |
mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/751f4dad2db84b0f893ba0445a18b1bd |
| work_keys_str_mv |
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