Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.

<h4>Rationale</h4>Recently it has been shown that long-term intensive exercise practice is able to induce myocardial fibrosis in an animal model. Angiotensin II is a profibrotic hormone that could be involved in the cardiac remodeling resulting from endurance exercise.<h4>Objective...

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Autores principales:	Gemma Gay-Jordi, Eduard Guash, Begoña Benito, Josep Brugada, Stanley Nattel, Lluís Mont, Anna Serrano-Mollar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/75232aaab4c94c0398364ea238fa2b1a
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spelling	oai:doaj.org-article:75232aaab4c94c0398364ea238fa2b1a2021-11-18T07:58:59ZLosartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.1932-620310.1371/journal.pone.0055427https://doaj.org/article/75232aaab4c94c0398364ea238fa2b1a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23383330/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Rationale</h4>Recently it has been shown that long-term intensive exercise practice is able to induce myocardial fibrosis in an animal model. Angiotensin II is a profibrotic hormone that could be involved in the cardiac remodeling resulting from endurance exercise.<h4>Objective</h4>This study examined the antifibrotic effect of losartan, an angiotensin II type 1 receptor antagonist, in an animal model of heart fibrosis induced by long-term intense exercise.<h4>Methods and results</h4>Male Wistar rats were randomly distributed into 4 experimental groups: Exercise, Exercise plus losartan, Sedentary and Sedentary plus losartan. Exercise groups were conditioned to run vigorously for 16 weeks. Losartan was orally administered daily before each training session (50 mg/kg/day). Time-matched sedentary rats served as controls. After euthanasia, heart hypertrophy was evaluated by histological studies; ventricular collagen deposition was quantified by histological and biochemical studies; and messenger RNA and protein expression of transforming growth factor-β1, fibronectin-1, matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1, procollagen-I and procollagen-III was evaluated in all 4 cardiac chambers. Daily intensive exercise caused hypertrophy in the left ventricular heart wall and originated collagen deposition in the right ventricle. Additionally long-term intensive exercise induced a significant increase in messenger RNA expression and protein synthesis of the major fibrotic markers in both atria and in the right ventricle. Losartan treatment was able to reduce all increases in messenger RNA expression and protein levels caused by exercise, although it could not completely reverse the heart hypertrophy.<h4>Conclusions</h4>Losartan treatment prevents the heart fibrosis induced by endurance exercise in training animals.Gemma Gay-JordiEduard GuashBegoña BenitoJosep BrugadaStanley NattelLluís MontAnna Serrano-MollarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55427 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gemma Gay-Jordi Eduard Guash Begoña Benito Josep Brugada Stanley Nattel Lluís Mont Anna Serrano-Mollar Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
description	<h4>Rationale</h4>Recently it has been shown that long-term intensive exercise practice is able to induce myocardial fibrosis in an animal model. Angiotensin II is a profibrotic hormone that could be involved in the cardiac remodeling resulting from endurance exercise.<h4>Objective</h4>This study examined the antifibrotic effect of losartan, an angiotensin II type 1 receptor antagonist, in an animal model of heart fibrosis induced by long-term intense exercise.<h4>Methods and results</h4>Male Wistar rats were randomly distributed into 4 experimental groups: Exercise, Exercise plus losartan, Sedentary and Sedentary plus losartan. Exercise groups were conditioned to run vigorously for 16 weeks. Losartan was orally administered daily before each training session (50 mg/kg/day). Time-matched sedentary rats served as controls. After euthanasia, heart hypertrophy was evaluated by histological studies; ventricular collagen deposition was quantified by histological and biochemical studies; and messenger RNA and protein expression of transforming growth factor-β1, fibronectin-1, matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1, procollagen-I and procollagen-III was evaluated in all 4 cardiac chambers. Daily intensive exercise caused hypertrophy in the left ventricular heart wall and originated collagen deposition in the right ventricle. Additionally long-term intensive exercise induced a significant increase in messenger RNA expression and protein synthesis of the major fibrotic markers in both atria and in the right ventricle. Losartan treatment was able to reduce all increases in messenger RNA expression and protein levels caused by exercise, although it could not completely reverse the heart hypertrophy.<h4>Conclusions</h4>Losartan treatment prevents the heart fibrosis induced by endurance exercise in training animals.
format	article
author	Gemma Gay-Jordi Eduard Guash Begoña Benito Josep Brugada Stanley Nattel Lluís Mont Anna Serrano-Mollar
author_facet	Gemma Gay-Jordi Eduard Guash Begoña Benito Josep Brugada Stanley Nattel Lluís Mont Anna Serrano-Mollar
author_sort	Gemma Gay-Jordi
title	Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
title_short	Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
title_full	Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
title_fullStr	Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
title_full_unstemmed	Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
title_sort	losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/75232aaab4c94c0398364ea238fa2b1a
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Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model.

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