Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite

ABSTRACT The most advanced vaccine against Plasmodium falciparum malaria, RTS,S/AS01, provides partial protection in infants and children living in areas of malaria endemicity. Further understanding its mechanisms of protection may allow the development of improved second-generation vaccines. The RT...

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Autor principal:	Johanna Patricia Daily
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	antimalarial vaccine malaria immunity malaria pathogenesis Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/752aa5c3155d4b1c858b581c9f8bfb76
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spelling	oai:doaj.org-article:752aa5c3155d4b1c858b581c9f8bfb762021-11-15T15:52:20ZShedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite10.1128/mBio.02555-182150-7511https://doaj.org/article/752aa5c3155d4b1c858b581c9f8bfb762018-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02555-18https://doaj.org/toc/2150-7511ABSTRACT The most advanced vaccine against Plasmodium falciparum malaria, RTS,S/AS01, provides partial protection in infants and children living in areas of malaria endemicity. Further understanding its mechanisms of protection may allow the development of improved second-generation vaccines. The RTS,S/AS01 vaccine targets the sporozoites injected by mosquito vectors into the dermis which then travel into the blood stream to establish infection in the liver. Flores-Garcia et al. (Y. Flores-Garcia, G. Nasir, C. S. Hopp, C. Munoz, et al., mBio 9:e02194-18, 2018, https://doi.org/10.1128/mBio.02194-18) shed light on early protective responses occurring in the dermis in immunized animals. They demonstrated that immunization impairs sporozoite motility and entry into blood vessels. Furthermore, they established that challenge experiments performed using a dermal route conferred greater protection than intravenous challenge in immunized mice. Thus, the dermal challenge approach captures the additional protective mechanisms occurring in the dermis that reflect the natural physiology of infection. Those studies highlighted the fascinating biology of skin-stage sporozoites and provided additional insights into vaccine-induced protection.Johanna Patricia DailyAmerican Society for Microbiologyarticleantimalarial vaccinemalaria immunitymalaria pathogenesisMicrobiologyQR1-502ENmBio, Vol 9, Iss 6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimalarial vaccine malaria immunity malaria pathogenesis Microbiology QR1-502
spellingShingle	antimalarial vaccine malaria immunity malaria pathogenesis Microbiology QR1-502 Johanna Patricia Daily Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite
description	ABSTRACT The most advanced vaccine against Plasmodium falciparum malaria, RTS,S/AS01, provides partial protection in infants and children living in areas of malaria endemicity. Further understanding its mechanisms of protection may allow the development of improved second-generation vaccines. The RTS,S/AS01 vaccine targets the sporozoites injected by mosquito vectors into the dermis which then travel into the blood stream to establish infection in the liver. Flores-Garcia et al. (Y. Flores-Garcia, G. Nasir, C. S. Hopp, C. Munoz, et al., mBio 9:e02194-18, 2018, https://doi.org/10.1128/mBio.02194-18) shed light on early protective responses occurring in the dermis in immunized animals. They demonstrated that immunization impairs sporozoite motility and entry into blood vessels. Furthermore, they established that challenge experiments performed using a dermal route conferred greater protection than intravenous challenge in immunized mice. Thus, the dermal challenge approach captures the additional protective mechanisms occurring in the dermis that reflect the natural physiology of infection. Those studies highlighted the fascinating biology of skin-stage sporozoites and provided additional insights into vaccine-induced protection.
format	article
author	Johanna Patricia Daily
author_facet	Johanna Patricia Daily
author_sort	Johanna Patricia Daily
title	Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite
title_short	Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite
title_full	Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite
title_fullStr	Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite
title_full_unstemmed	Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite
title_sort	shedding light on the role of the skin in vaccine-induced protection against the malaria sporozoite
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/752aa5c3155d4b1c858b581c9f8bfb76
work_keys_str_mv	AT johannapatriciadaily sheddinglightontheroleoftheskininvaccineinducedprotectionagainstthemalariasporozoite
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Shedding Light on the Role of the Skin in Vaccine-Induced Protection against the Malaria Sporozoite

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