Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease
Abstract The effect of the skin–capsular distance (SCD) on the controlled attenuation parameter (CAP) for diagnosis of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD) remains unclear. The SCD was measured using B-mode ultrasound, and the CAP was measured using the M probe o...
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Nature Portfolio
2021
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oai:doaj.org-article:752b957dfd2049568bbe65970f4665562021-12-02T16:35:28ZEffect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease10.1038/s41598-021-94970-32045-2322https://doaj.org/article/752b957dfd2049568bbe65970f4665562021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94970-3https://doaj.org/toc/2045-2322Abstract The effect of the skin–capsular distance (SCD) on the controlled attenuation parameter (CAP) for diagnosis of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD) remains unclear. The SCD was measured using B-mode ultrasound, and the CAP was measured using the M probe of FibroScan®. According to the indications of the M probe, 113 patients with an SCD of ≤ 25 mm were included in the present study. The association between the SCD and CAP was investigated, and the diagnostic performance of the SCD-adjusted CAP was tested. The SCD showed the most significant positive correlation with the CAP (ρ = 0.329, p < 0.001). In the multiple regression analysis, the SCD and serum albumin concentration were associated with the CAP, independent of pathological liver steatosis. According to the multivariate analysis, two different formulas were developed to obtain the adjusted CAP using the SCD and serum albumin concentration as follows: adjusted CAP (dB/m) = CAP − (5.26 × SCD) and adjusted CAP (dB/m) = CAP − (5.35 × SCD) − (25.77 × serum albumin concentration). The area under the receiver operating characteristic curve for diagnosis of a steatosis score ≥ 2 of adjusted CAP was 0.678 and 0.684 respectively, which were significantly greater than the original CAP (0.621: p = 0.030 and p = 0.024). The SCD is associated with the CAP independent of liver steatosis. Adjustment of the CAP using the SCD improves the diagnostic performance of the CAP in NAFLD.Syunichiro KimuraKenichi TanakaSatoshi OedaKaori InoueChika InadomiYoshihito KubotsuWataru YoshiokaMichiaki OkadaHiroshi IsodaTakuya KuwashiroTakumi AkiyamaAya KurashigeAyaka OshimaMayumi OshimaYasue MatsumotoAtsushi KawaguchiKeizo AnzaiEisaburo SueokaShinichi AishimaHirokazu TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Syunichiro Kimura Kenichi Tanaka Satoshi Oeda Kaori Inoue Chika Inadomi Yoshihito Kubotsu Wataru Yoshioka Michiaki Okada Hiroshi Isoda Takuya Kuwashiro Takumi Akiyama Aya Kurashige Ayaka Oshima Mayumi Oshima Yasue Matsumoto Atsushi Kawaguchi Keizo Anzai Eisaburo Sueoka Shinichi Aishima Hirokazu Takahashi Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| description |
Abstract The effect of the skin–capsular distance (SCD) on the controlled attenuation parameter (CAP) for diagnosis of liver steatosis in patients with nonalcoholic fatty liver disease (NAFLD) remains unclear. The SCD was measured using B-mode ultrasound, and the CAP was measured using the M probe of FibroScan®. According to the indications of the M probe, 113 patients with an SCD of ≤ 25 mm were included in the present study. The association between the SCD and CAP was investigated, and the diagnostic performance of the SCD-adjusted CAP was tested. The SCD showed the most significant positive correlation with the CAP (ρ = 0.329, p < 0.001). In the multiple regression analysis, the SCD and serum albumin concentration were associated with the CAP, independent of pathological liver steatosis. According to the multivariate analysis, two different formulas were developed to obtain the adjusted CAP using the SCD and serum albumin concentration as follows: adjusted CAP (dB/m) = CAP − (5.26 × SCD) and adjusted CAP (dB/m) = CAP − (5.35 × SCD) − (25.77 × serum albumin concentration). The area under the receiver operating characteristic curve for diagnosis of a steatosis score ≥ 2 of adjusted CAP was 0.678 and 0.684 respectively, which were significantly greater than the original CAP (0.621: p = 0.030 and p = 0.024). The SCD is associated with the CAP independent of liver steatosis. Adjustment of the CAP using the SCD improves the diagnostic performance of the CAP in NAFLD. |
| format |
article |
| author |
Syunichiro Kimura Kenichi Tanaka Satoshi Oeda Kaori Inoue Chika Inadomi Yoshihito Kubotsu Wataru Yoshioka Michiaki Okada Hiroshi Isoda Takuya Kuwashiro Takumi Akiyama Aya Kurashige Ayaka Oshima Mayumi Oshima Yasue Matsumoto Atsushi Kawaguchi Keizo Anzai Eisaburo Sueoka Shinichi Aishima Hirokazu Takahashi |
| author_facet |
Syunichiro Kimura Kenichi Tanaka Satoshi Oeda Kaori Inoue Chika Inadomi Yoshihito Kubotsu Wataru Yoshioka Michiaki Okada Hiroshi Isoda Takuya Kuwashiro Takumi Akiyama Aya Kurashige Ayaka Oshima Mayumi Oshima Yasue Matsumoto Atsushi Kawaguchi Keizo Anzai Eisaburo Sueoka Shinichi Aishima Hirokazu Takahashi |
| author_sort |
Syunichiro Kimura |
| title |
Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| title_short |
Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| title_full |
Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| title_fullStr |
Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| title_full_unstemmed |
Effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| title_sort |
effect of skin–capsular distance on controlled attenuation parameter for diagnosing liver steatosis in patients with nonalcoholic fatty liver disease |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/752b957dfd2049568bbe65970f466556 |
| work_keys_str_mv |
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1718383698245582848 |