Minimal-moderate variation of human oral virome and microbiome in IgA deficiency

Abstract Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our comm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Maria José de la Cruz Peña, Luis Ignacio Gonzalez-Granado, Inmaculada Garcia-Heredia, Lucia Maestre Carballa, Manuel Martinez-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/752c691682d943b5b1978b536a1e4326
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:752c691682d943b5b1978b536a1e4326
record_format	dspace
spelling	oai:doaj.org-article:752c691682d943b5b1978b536a1e43262021-12-02T16:17:21ZMinimal-moderate variation of human oral virome and microbiome in IgA deficiency10.1038/s41598-021-94507-82045-2322https://doaj.org/article/752c691682d943b5b1978b536a1e43262021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94507-8https://doaj.org/toc/2045-2322Abstract Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency and also common variable IgA and IgM immunodeficiencies (CVID), on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency and CVID indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (two fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results demonstrate that, within the limits of our cohort, IgA role is not critical for maintaining a rather functional salivary microbiome and suggest that IgA is not a major influence on the composition of abundant commensal microbes.Maria José de la Cruz PeñaLuis Ignacio Gonzalez-GranadoInmaculada Garcia-HerediaLucia Maestre CarballaManuel Martinez-GarciaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria José de la Cruz Peña Luis Ignacio Gonzalez-Granado Inmaculada Garcia-Heredia Lucia Maestre Carballa Manuel Martinez-Garcia Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
description	Abstract Immunoglobulin A (IgA) is the dominant antibody found in our mucosal secretions and has long been recognized to play an important role in protecting our epithelium from pathogens. Recently, IgA has been shown to be involved in gut homeostatic regulation by ‘recognizing’ and shaping our commensal microbes. Paradoxically, yet selective IgA-deficiency is often described as asymptomatic and there is a paucity of studies only focused on the mice and human gut microbiome context fully ignoring other niches of our body and our commensal viruses. Here, we used as a model the human oral cavity and employed a holistic view and studied the impact of IgA deficiency and also common variable IgA and IgM immunodeficiencies (CVID), on both the human virome and microbiome. Unexpectedly, metagenomic and experimental data in human IgA deficiency and CVID indicate minimal-moderate changes in microbiome and virome composition compared to healthy control group and point out to a rather functional, resilient oral commensal viruses and microbes. However, a significant depletion (two fold) of bacterial cells (p-value < 0.01) and viruses was observed in IgA-deficiency. Our results demonstrate that, within the limits of our cohort, IgA role is not critical for maintaining a rather functional salivary microbiome and suggest that IgA is not a major influence on the composition of abundant commensal microbes.
format	article
author	Maria José de la Cruz Peña Luis Ignacio Gonzalez-Granado Inmaculada Garcia-Heredia Lucia Maestre Carballa Manuel Martinez-Garcia
author_facet	Maria José de la Cruz Peña Luis Ignacio Gonzalez-Granado Inmaculada Garcia-Heredia Lucia Maestre Carballa Manuel Martinez-Garcia
author_sort	Maria José de la Cruz Peña
title	Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
title_short	Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
title_full	Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
title_fullStr	Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
title_full_unstemmed	Minimal-moderate variation of human oral virome and microbiome in IgA deficiency
title_sort	minimal-moderate variation of human oral virome and microbiome in iga deficiency
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/752c691682d943b5b1978b536a1e4326
work_keys_str_mv	AT mariajosedelacruzpena minimalmoderatevariationofhumanoralviromeandmicrobiomeinigadeficiency AT luisignaciogonzalezgranado minimalmoderatevariationofhumanoralviromeandmicrobiomeinigadeficiency AT inmaculadagarciaheredia minimalmoderatevariationofhumanoralviromeandmicrobiomeinigadeficiency AT luciamaestrecarballa minimalmoderatevariationofhumanoralviromeandmicrobiomeinigadeficiency AT manuelmartinezgarcia minimalmoderatevariationofhumanoralviromeandmicrobiomeinigadeficiency
_version_	1718384237549191168

Minimal-moderate variation of human oral virome and microbiome in IgA deficiency

Ejemplares similares