Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function

Li-Hong Pan,1,* Ming Qian,1,* Weihua Qu,2 Qin Tang,2 Yuzhong Yan3 1Department of Psychiatry, Shanghai Pudong Nanhui Mental Health Center, Shanghai, People’s Republic of China; 2Department of Clinical Laboratory, Shanghai Prison General Hospital, Shanghai, People’s Republic of Chi...

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Autores principales:	Pan LH, Qian M, Qu W, Tang Q, Yan Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	schizophrenia deficit schizophrenia c-reactive protein inflammation cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/752f0906a8f84206b047c91bd2de44ed
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spelling	oai:doaj.org-article:752f0906a8f84206b047c91bd2de44ed2021-12-02T14:50:24ZSerum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function1178-2021https://doaj.org/article/752f0906a8f84206b047c91bd2de44ed2020-12-01T00:00:00Zhttps://www.dovepress.com/serum-c-reactive-protein-in-patients-with-deficit-schizophrenia-and-th-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Li-Hong Pan,1,* Ming Qian,1,* Weihua Qu,2 Qin Tang,2 Yuzhong Yan3 1Department of Psychiatry, Shanghai Pudong Nanhui Mental Health Center, Shanghai, People’s Republic of China; 2Department of Clinical Laboratory, Shanghai Prison General Hospital, Shanghai, People’s Republic of China; 3Department of Research, Shanghai University of Medicine and Health Science Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuzhong Yan Email jykwsw@126.comBackground: Serum levels of C-reactive protein (CRP) were measured in patients with deficit schizophrenia (DS) to confirm the association between CRP level and cognitive performance and to determine whether CRP was a new biological indicator with the potential clinical applications in DS patients.Methods: Three independent samples [41 DS and 50 non-deficit schizophrenia (NDS) and 30 sex- and age-matched healthy controls (HCs)] were recruited in our study. Serum CRP levels were measured by immunofluorescence. The Positive and Negative Syndrome Scale (PANSS) and alternative forms of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were also assessed. And the relationships between serum CRP levels and both PANSS and RBANS scores were finally analyzed.Results: The results of serum CRP level were showed significantly different among the three groups and increased from the HCs to NDS patients to DS patients. There were also significant differences in the cognitive subdomain analyses among the three groups. Serum CRP levels were found positively correlated with total and negative PANSS scores, and showed negatively correlated with overall cognitive test scores in the DS samples.Conclusion: Serum C-reactive protein levels and their association with cognitive performance were different between deficit schizophrenia and non-deficit schizophrenia samples, and higher serum CRP level was associated with worse cognitive performance in the DS patients. The results indicated that CRP could be a potential biomarker, and DS could be a distinct subset of schizophrenia.Keywords: schizophrenia, deficit schizophrenia, C-reactive protein, inflammation, cognitive impairmentPan LHQian MQu WTang QYan YDove Medical Pressarticleschizophreniadeficit schizophreniac-reactive proteininflammationcognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2891-2897 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia deficit schizophrenia c-reactive protein inflammation cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia deficit schizophrenia c-reactive protein inflammation cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Pan LH Qian M Qu W Tang Q Yan Y Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function
description	Li-Hong Pan,1,* Ming Qian,1,* Weihua Qu,2 Qin Tang,2 Yuzhong Yan3 1Department of Psychiatry, Shanghai Pudong Nanhui Mental Health Center, Shanghai, People’s Republic of China; 2Department of Clinical Laboratory, Shanghai Prison General Hospital, Shanghai, People’s Republic of China; 3Department of Research, Shanghai University of Medicine and Health Science Affiliated Zhoupu Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuzhong Yan Email jykwsw@126.comBackground: Serum levels of C-reactive protein (CRP) were measured in patients with deficit schizophrenia (DS) to confirm the association between CRP level and cognitive performance and to determine whether CRP was a new biological indicator with the potential clinical applications in DS patients.Methods: Three independent samples [41 DS and 50 non-deficit schizophrenia (NDS) and 30 sex- and age-matched healthy controls (HCs)] were recruited in our study. Serum CRP levels were measured by immunofluorescence. The Positive and Negative Syndrome Scale (PANSS) and alternative forms of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were also assessed. And the relationships between serum CRP levels and both PANSS and RBANS scores were finally analyzed.Results: The results of serum CRP level were showed significantly different among the three groups and increased from the HCs to NDS patients to DS patients. There were also significant differences in the cognitive subdomain analyses among the three groups. Serum CRP levels were found positively correlated with total and negative PANSS scores, and showed negatively correlated with overall cognitive test scores in the DS samples.Conclusion: Serum C-reactive protein levels and their association with cognitive performance were different between deficit schizophrenia and non-deficit schizophrenia samples, and higher serum CRP level was associated with worse cognitive performance in the DS patients. The results indicated that CRP could be a potential biomarker, and DS could be a distinct subset of schizophrenia.Keywords: schizophrenia, deficit schizophrenia, C-reactive protein, inflammation, cognitive impairment
format	article
author	Pan LH Qian M Qu W Tang Q Yan Y
author_facet	Pan LH Qian M Qu W Tang Q Yan Y
author_sort	Pan LH
title	Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function
title_short	Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function
title_full	Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function
title_fullStr	Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function
title_full_unstemmed	Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function
title_sort	serum c-reactive protein in patients with deficit schizophrenia and the relationship with cognitive function
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/752f0906a8f84206b047c91bd2de44ed
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Serum C-Reactive Protein in Patients with Deficit Schizophrenia and the Relationship with Cognitive Function

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