Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations

The susceptibility of the GAK rs1564282 variant in Parkinson’s disease (PD) in Europeans was identified using a series of published genome-wide association studies. Recently, some studies focused on the association between rs1564282 and PD risk in Chinese populations but with inconsistent results. T...

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Autores principales:	He Li, Chen Zhang, Yong Ji
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Parkinson’s disease genome-wide association study GAK rs1564282 Chinese population Genetics QH426-470
Acceso en línea:	https://doaj.org/article/75336b16815a487ab729eaef7d7b4cbd
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spelling	oai:doaj.org-article:75336b16815a487ab729eaef7d7b4cbd2021-11-18T09:45:06ZAssociation of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations1664-802110.3389/fgene.2021.777942https://doaj.org/article/75336b16815a487ab729eaef7d7b4cbd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.777942/fullhttps://doaj.org/toc/1664-8021The susceptibility of the GAK rs1564282 variant in Parkinson’s disease (PD) in Europeans was identified using a series of published genome-wide association studies. Recently, some studies focused on the association between rs1564282 and PD risk in Chinese populations but with inconsistent results. Thus, we conducted an updated meta-analysis with a total of 7,881 samples (4,055 PD cases and 3,826 controls) from eligible studies. After excluding significant heterogeneity, we showed that the rs1564282 variant was significantly associated with PD in Chinese populations (p = 1.00E-04, odds ratio = 1.28 and 95% confidence interval = 1.16–1.42). The sensitivity analysis showed that the association between rs1564282 and PD was not greatly influenced, and there was no significant publication bias among the included studies. Consequently, this meta-analysis indicates that the GAK rs1564282 variant is significantly associated with susceptibility to PD in Chinese populations.He LiChen ZhangYong JiFrontiers Media S.A.articleParkinson’s diseasegenome-wide association studyGAKrs1564282Chinese populationGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson’s disease genome-wide association study GAK rs1564282 Chinese population Genetics QH426-470
spellingShingle	Parkinson’s disease genome-wide association study GAK rs1564282 Chinese population Genetics QH426-470 He Li Chen Zhang Yong Ji Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations
description	The susceptibility of the GAK rs1564282 variant in Parkinson’s disease (PD) in Europeans was identified using a series of published genome-wide association studies. Recently, some studies focused on the association between rs1564282 and PD risk in Chinese populations but with inconsistent results. Thus, we conducted an updated meta-analysis with a total of 7,881 samples (4,055 PD cases and 3,826 controls) from eligible studies. After excluding significant heterogeneity, we showed that the rs1564282 variant was significantly associated with PD in Chinese populations (p = 1.00E-04, odds ratio = 1.28 and 95% confidence interval = 1.16–1.42). The sensitivity analysis showed that the association between rs1564282 and PD was not greatly influenced, and there was no significant publication bias among the included studies. Consequently, this meta-analysis indicates that the GAK rs1564282 variant is significantly associated with susceptibility to PD in Chinese populations.
format	article
author	He Li Chen Zhang Yong Ji
author_facet	He Li Chen Zhang Yong Ji
author_sort	He Li
title	Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations
title_short	Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations
title_full	Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations
title_fullStr	Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations
title_full_unstemmed	Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations
title_sort	association of gak rs1564282 with susceptibility to parkinson’s disease in chinese populations
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/75336b16815a487ab729eaef7d7b4cbd
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Association of GAK rs1564282 With Susceptibility to Parkinson’s Disease in Chinese Populations

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