Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography

Abstract Background The origin of cough in dogs with heart murmurs is controversial, because the cough could be primary cardiac (eg, pulmonary edema, bronchi compression by left‐sided cardiomegaly) or respiratory (eg, bronchomalacia, other bronchial or bronchiolar disease, interstitial lung disease)...

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Autores principales:	Matthieu Lebastard, Kevin Le Boedec, Mark Howes, Stephen Joslyn, Jodi S. Matheson, Robert T. O'Brien
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bronchomalacia canine cardiomegaly vertebral heart scale Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/7534a21af11c4eb5ad8e4c612514d6f0
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spelling	oai:doaj.org-article:7534a21af11c4eb5ad8e4c612514d6f02021-11-30T17:01:04ZEvaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography1939-16760891-664010.1111/jvim.16115https://doaj.org/article/7534a21af11c4eb5ad8e4c612514d6f02021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16115https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background The origin of cough in dogs with heart murmurs is controversial, because the cough could be primary cardiac (eg, pulmonary edema, bronchi compression by left‐sided cardiomegaly) or respiratory (eg, bronchomalacia, other bronchial or bronchiolar disease, interstitial lung disease) in origin. Hypothesis/Objectives To study the association between left atrium (LA) dilatation and cardiomegaly and bronchial narrowing in coughing dogs with heart murmurs using computed tomography (CT). Animals Twenty‐one client‐owned coughing dogs with heart murmurs and 14 historical control dogs. Methods Dogs with cough and murmur were prospectively recruited over 4 months. Cervical and thoracic radiography, echocardiography, and thoracic CT were performed in enrolled dogs. Control dogs, with no disease on thoracic CT and no records of heart murmur and coughing, were gathered from the institution's computerized database. Degree of bronchial narrowing was assessed using the bronchial‐to‐aorta (Ao) ratio, measured by 3 radiologists blinded to the clinical findings. After identifying bronchi that were significantly narrowed in dogs with murmur compared to controls, the relationship between degree of narrowing and LA/Ao ratio (measured echocardiographically) and vertebral heart scale (VHS) measured radiographically was studied in dogs with murmur using mixed‐effects regression. Result Significant narrowing was identified for all left‐sided bronchi and the right principal, middle, and caudal bronchi in the coughing dogs, compared with controls. Increasing LA size and VHS were significantly inversely associated with diameter for all left‐sided and right‐sided bronchi indicated above. Conclusion and Clinical Importance Results indicate an association between LA enlargement and cardiomegaly and bronchial narrowing and support heart size‐associated exacerbation of cough in dogs with murmurs.Matthieu LebastardKevin Le BoedecMark HowesStephen JoslynJodi S. MathesonRobert T. O'BrienWileyarticlebronchomalaciacaninecardiomegalyvertebral heart scaleVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1509-1518 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchomalacia canine cardiomegaly vertebral heart scale Veterinary medicine SF600-1100
spellingShingle	bronchomalacia canine cardiomegaly vertebral heart scale Veterinary medicine SF600-1100 Matthieu Lebastard Kevin Le Boedec Mark Howes Stephen Joslyn Jodi S. Matheson Robert T. O'Brien Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
description	Abstract Background The origin of cough in dogs with heart murmurs is controversial, because the cough could be primary cardiac (eg, pulmonary edema, bronchi compression by left‐sided cardiomegaly) or respiratory (eg, bronchomalacia, other bronchial or bronchiolar disease, interstitial lung disease) in origin. Hypothesis/Objectives To study the association between left atrium (LA) dilatation and cardiomegaly and bronchial narrowing in coughing dogs with heart murmurs using computed tomography (CT). Animals Twenty‐one client‐owned coughing dogs with heart murmurs and 14 historical control dogs. Methods Dogs with cough and murmur were prospectively recruited over 4 months. Cervical and thoracic radiography, echocardiography, and thoracic CT were performed in enrolled dogs. Control dogs, with no disease on thoracic CT and no records of heart murmur and coughing, were gathered from the institution's computerized database. Degree of bronchial narrowing was assessed using the bronchial‐to‐aorta (Ao) ratio, measured by 3 radiologists blinded to the clinical findings. After identifying bronchi that were significantly narrowed in dogs with murmur compared to controls, the relationship between degree of narrowing and LA/Ao ratio (measured echocardiographically) and vertebral heart scale (VHS) measured radiographically was studied in dogs with murmur using mixed‐effects regression. Result Significant narrowing was identified for all left‐sided bronchi and the right principal, middle, and caudal bronchi in the coughing dogs, compared with controls. Increasing LA size and VHS were significantly inversely associated with diameter for all left‐sided and right‐sided bronchi indicated above. Conclusion and Clinical Importance Results indicate an association between LA enlargement and cardiomegaly and bronchial narrowing and support heart size‐associated exacerbation of cough in dogs with murmurs.
format	article
author	Matthieu Lebastard Kevin Le Boedec Mark Howes Stephen Joslyn Jodi S. Matheson Robert T. O'Brien
author_facet	Matthieu Lebastard Kevin Le Boedec Mark Howes Stephen Joslyn Jodi S. Matheson Robert T. O'Brien
author_sort	Matthieu Lebastard
title	Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
title_short	Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
title_full	Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
title_fullStr	Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
title_full_unstemmed	Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
title_sort	evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/7534a21af11c4eb5ad8e4c612514d6f0
work_keys_str_mv	AT matthieulebastard evaluationofbronchialnarrowingincoughingdogswithheartmurmursusingcomputedtomography AT kevinleboedec evaluationofbronchialnarrowingincoughingdogswithheartmurmursusingcomputedtomography AT markhowes evaluationofbronchialnarrowingincoughingdogswithheartmurmursusingcomputedtomography AT stephenjoslyn evaluationofbronchialnarrowingincoughingdogswithheartmurmursusingcomputedtomography AT jodismatheson evaluationofbronchialnarrowingincoughingdogswithheartmurmursusingcomputedtomography AT roberttobrien evaluationofbronchialnarrowingincoughingdogswithheartmurmursusingcomputedtomography
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Evaluation of bronchial narrowing in coughing dogs with heart murmurs using computed tomography

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