Mitochondrial genetic variants identified to be associated with BMI in adults.

It has been suggested that mitochondrial dysfunction plays a role in metabolic disorders including obesity, diabetes, and hypertension. The fact that mitochondrial defects can be accumulated over time as a normal part of aging may explain why some individuals can eat all sorts of foods and remain at...

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Autores principales:	Antònia Flaquer, Clemens Baumbach, Jennifer Kriebel, Thomas Meitinger, Annette Peters, Melanie Waldenberger, Harald Grallert, Konstantin Strauch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7536084a86e9404b86d325a75fb2039e
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spelling	oai:doaj.org-article:7536084a86e9404b86d325a75fb2039e2021-11-25T06:03:16ZMitochondrial genetic variants identified to be associated with BMI in adults.1932-620310.1371/journal.pone.0105116https://doaj.org/article/7536084a86e9404b86d325a75fb2039e2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25153900/?tool=EBIhttps://doaj.org/toc/1932-6203It has been suggested that mitochondrial dysfunction plays a role in metabolic disorders including obesity, diabetes, and hypertension. The fact that mitochondrial defects can be accumulated over time as a normal part of aging may explain why some individuals can eat all sorts of foods and remain at normal weight while they are young. However, around the fourth decade of life there is a trend towards "middle-age spread" with weight gain and the body's decreasing ability to metabolize calories efficiently. To test the hypothesis that mitochondrial variants are associated with BMI in adults, we analyzed a total number of 984 mitochondrial single nucleotide polymorphisms (mtSNPs) in a sample of 6,528 individuals participating in the KORA studies. To assess mtSNP association while taking heteroplasmy into account we used the raw signal intensity values measured on the microarray and applied linear regression. Significant results were obtained for 2 mtSNPs located in the Cytochrome c oxidase subunit genes (MT-CO1: Padjusted = 0.0140 and MT-CO3: Padjusted = 0.0286) and 3 mtSNPs located in the NADH dehydrogenase subunit genes (MT-ND1, MT-ND2 and MT-ND4L: Padjusted = 0.0286). Polymorphisms located in the MT-CO3 and MT-ND4L genes have not been associated with BMI or related phenotypes in the past. Our results highlight the importance of the mitochondrial genome among the factors that contribute to the risk of high BMI. Focusing on mitochondrial variants may lead to further insights regarding effects of existing medications, or even to the development of innovative treatments.Antònia FlaquerClemens BaumbachJennifer KriebelThomas MeitingerAnnette PetersMelanie WaldenbergerHarald GrallertKonstantin StrauchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105116 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antònia Flaquer Clemens Baumbach Jennifer Kriebel Thomas Meitinger Annette Peters Melanie Waldenberger Harald Grallert Konstantin Strauch Mitochondrial genetic variants identified to be associated with BMI in adults.
description	It has been suggested that mitochondrial dysfunction plays a role in metabolic disorders including obesity, diabetes, and hypertension. The fact that mitochondrial defects can be accumulated over time as a normal part of aging may explain why some individuals can eat all sorts of foods and remain at normal weight while they are young. However, around the fourth decade of life there is a trend towards "middle-age spread" with weight gain and the body's decreasing ability to metabolize calories efficiently. To test the hypothesis that mitochondrial variants are associated with BMI in adults, we analyzed a total number of 984 mitochondrial single nucleotide polymorphisms (mtSNPs) in a sample of 6,528 individuals participating in the KORA studies. To assess mtSNP association while taking heteroplasmy into account we used the raw signal intensity values measured on the microarray and applied linear regression. Significant results were obtained for 2 mtSNPs located in the Cytochrome c oxidase subunit genes (MT-CO1: Padjusted = 0.0140 and MT-CO3: Padjusted = 0.0286) and 3 mtSNPs located in the NADH dehydrogenase subunit genes (MT-ND1, MT-ND2 and MT-ND4L: Padjusted = 0.0286). Polymorphisms located in the MT-CO3 and MT-ND4L genes have not been associated with BMI or related phenotypes in the past. Our results highlight the importance of the mitochondrial genome among the factors that contribute to the risk of high BMI. Focusing on mitochondrial variants may lead to further insights regarding effects of existing medications, or even to the development of innovative treatments.
format	article
author	Antònia Flaquer Clemens Baumbach Jennifer Kriebel Thomas Meitinger Annette Peters Melanie Waldenberger Harald Grallert Konstantin Strauch
author_facet	Antònia Flaquer Clemens Baumbach Jennifer Kriebel Thomas Meitinger Annette Peters Melanie Waldenberger Harald Grallert Konstantin Strauch
author_sort	Antònia Flaquer
title	Mitochondrial genetic variants identified to be associated with BMI in adults.
title_short	Mitochondrial genetic variants identified to be associated with BMI in adults.
title_full	Mitochondrial genetic variants identified to be associated with BMI in adults.
title_fullStr	Mitochondrial genetic variants identified to be associated with BMI in adults.
title_full_unstemmed	Mitochondrial genetic variants identified to be associated with BMI in adults.
title_sort	mitochondrial genetic variants identified to be associated with bmi in adults.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7536084a86e9404b86d325a75fb2039e
work_keys_str_mv	AT antoniaflaquer mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT clemensbaumbach mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT jenniferkriebel mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT thomasmeitinger mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT annettepeters mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT melaniewaldenberger mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT haraldgrallert mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults AT konstantinstrauch mitochondrialgeneticvariantsidentifiedtobeassociatedwithbmiinadults
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Mitochondrial genetic variants identified to be associated with BMI in adults.

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