Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.

<h4>Objectives</h4>To investigate whether partner bereavement is associated with adverse cardiovascular and kidney-related events in people with reduced kidney function.<h4>Design</h4>Two parallel matched cohort studies using linked routinely collected health data.<h4>S...

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Autores principales:	Patrick Bidulka, Søren Viborg Vestergaard, Admire Hlupeni, Anders Kjærsgaard, Angel Y S Wong, Sinéad M Langan, Sigrun Alba Johannesdottir Schmidt, Susan Lyon, Christian Fynbo Christiansen, Dorothea Nitsch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/753758a7316f4d938b220ef2fc412514
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spelling	oai:doaj.org-article:753758a7316f4d938b220ef2fc4125142021-12-02T20:06:11ZAdverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.1932-620310.1371/journal.pone.0257255https://doaj.org/article/753758a7316f4d938b220ef2fc4125142021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257255https://doaj.org/toc/1932-6203<h4>Objectives</h4>To investigate whether partner bereavement is associated with adverse cardiovascular and kidney-related events in people with reduced kidney function.<h4>Design</h4>Two parallel matched cohort studies using linked routinely collected health data.<h4>Setting</h4>England (general practices and hospitals using linked Clinical Practice Research Datalink, Hospital Episode Statistics, and Office of National Statistics) and Denmark (hospitals and community pharmacies using the Danish National Patient, Prescription and Education Registries and the Civil Registration System).<h4>Participants</h4>Bereaved people with reduced kidney function (estimated glomerular filtration rate (eGFR) <60mL/min/1.73m2 (England) or hospital-coded chronic kidney disease (Denmark)) and non-bereaved people with reduced kidney function similarly defined, matched on age, sex, general practice (England), and county of residence (Denmark) and followed-up from the bereavement date of the exposed person.<h4>Main outcome measures</h4>Cardiovascular disease (CVD) or acute kidney injury (AKI) hospitalization, or death.<h4>Results</h4>In people with reduced kidney function, we identified 19,820 (England) and 5,408 (Denmark) bereaved individuals and matched them with 134,828 (England) and 35,741 (Denmark) non-bereaved individuals. Among the bereaved, the rates of hospitalizations (per 1000 person-years) with CVD were 31.7 (95%-CI: 30.5-32.9) in England and 78.8 (95%-CI: 74.9-82.9) in Denmark; the rates of hospitalizations with AKI were 13.2 (95%-CI: 12.5-14.0) in England and 11.2 (95%-CI: 9.9-12.7) in Denmark; and the rates of death were 70.2 (95%-CI: 68.5-72.0) in England and 126.4 (95%-CI: 121.8-131.1) in Denmark. After adjusting for confounders, we found increased rates of CVD (England, HR 1.06 [95%-CI: 1.01-1.12]; Denmark, HR 1.10 [95%-CI: 1.04-1.17]), of AKI (England, HR 1.20 [95%-CI: 1.10-1.31]; Denmark HR 1.36 [95%-CI: 1.17-1.58]), and of death (England, HR 1.10 [95%-CI: 1.05-1.14]; Denmark HR 1.20 [95%-CI: 1.15-1.25]) in bereaved compared with non-bereaved people.<h4>Conclusions</h4>Partner bereavement is associated with an increased rate of CVD and AKI hospitalization, and death in people with reduced kidney function. Additional supportive care for this at-risk population may help prevent serious adverse events.Patrick BidulkaSøren Viborg VestergaardAdmire HlupeniAnders KjærsgaardAngel Y S WongSinéad M LanganSigrun Alba Johannesdottir SchmidtSusan LyonChristian Fynbo ChristiansenDorothea NitschPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257255 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick Bidulka Søren Viborg Vestergaard Admire Hlupeni Anders Kjærsgaard Angel Y S Wong Sinéad M Langan Sigrun Alba Johannesdottir Schmidt Susan Lyon Christian Fynbo Christiansen Dorothea Nitsch Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.
description	<h4>Objectives</h4>To investigate whether partner bereavement is associated with adverse cardiovascular and kidney-related events in people with reduced kidney function.<h4>Design</h4>Two parallel matched cohort studies using linked routinely collected health data.<h4>Setting</h4>England (general practices and hospitals using linked Clinical Practice Research Datalink, Hospital Episode Statistics, and Office of National Statistics) and Denmark (hospitals and community pharmacies using the Danish National Patient, Prescription and Education Registries and the Civil Registration System).<h4>Participants</h4>Bereaved people with reduced kidney function (estimated glomerular filtration rate (eGFR) <60mL/min/1.73m2 (England) or hospital-coded chronic kidney disease (Denmark)) and non-bereaved people with reduced kidney function similarly defined, matched on age, sex, general practice (England), and county of residence (Denmark) and followed-up from the bereavement date of the exposed person.<h4>Main outcome measures</h4>Cardiovascular disease (CVD) or acute kidney injury (AKI) hospitalization, or death.<h4>Results</h4>In people with reduced kidney function, we identified 19,820 (England) and 5,408 (Denmark) bereaved individuals and matched them with 134,828 (England) and 35,741 (Denmark) non-bereaved individuals. Among the bereaved, the rates of hospitalizations (per 1000 person-years) with CVD were 31.7 (95%-CI: 30.5-32.9) in England and 78.8 (95%-CI: 74.9-82.9) in Denmark; the rates of hospitalizations with AKI were 13.2 (95%-CI: 12.5-14.0) in England and 11.2 (95%-CI: 9.9-12.7) in Denmark; and the rates of death were 70.2 (95%-CI: 68.5-72.0) in England and 126.4 (95%-CI: 121.8-131.1) in Denmark. After adjusting for confounders, we found increased rates of CVD (England, HR 1.06 [95%-CI: 1.01-1.12]; Denmark, HR 1.10 [95%-CI: 1.04-1.17]), of AKI (England, HR 1.20 [95%-CI: 1.10-1.31]; Denmark HR 1.36 [95%-CI: 1.17-1.58]), and of death (England, HR 1.10 [95%-CI: 1.05-1.14]; Denmark HR 1.20 [95%-CI: 1.15-1.25]) in bereaved compared with non-bereaved people.<h4>Conclusions</h4>Partner bereavement is associated with an increased rate of CVD and AKI hospitalization, and death in people with reduced kidney function. Additional supportive care for this at-risk population may help prevent serious adverse events.
format	article
author	Patrick Bidulka Søren Viborg Vestergaard Admire Hlupeni Anders Kjærsgaard Angel Y S Wong Sinéad M Langan Sigrun Alba Johannesdottir Schmidt Susan Lyon Christian Fynbo Christiansen Dorothea Nitsch
author_facet	Patrick Bidulka Søren Viborg Vestergaard Admire Hlupeni Anders Kjærsgaard Angel Y S Wong Sinéad M Langan Sigrun Alba Johannesdottir Schmidt Susan Lyon Christian Fynbo Christiansen Dorothea Nitsch
author_sort	Patrick Bidulka
title	Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.
title_short	Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.
title_full	Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.
title_fullStr	Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.
title_full_unstemmed	Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.
title_sort	adverse outcomes after partner bereavement in people with reduced kidney function: parallel cohort studies in england and denmark.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/753758a7316f4d938b220ef2fc412514
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Adverse outcomes after partner bereavement in people with reduced kidney function: Parallel cohort studies in England and Denmark.

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