Decreased amygdala volume in adults after premature birth

Abstract Premature-born infants have impaired amygdala structure, presumably due to increased stress levels of premature birth mediated by the amygdala. However, accounting for lifelong plasticity of amygdala, it is unclear whether such structural changes persist into adulthood. To address this prob...

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Autores principales:	Benita Schmitz-Koep, Juliana Zimmermann, Aurore Menegaux, Rachel Nuttall, Josef G. Bäuml, Sebastian C. Schneider, Marcel Daamen, Henning Boecker, Claus Zimmer, Dieter Wolke, Peter Bartmann, Dennis M. Hedderich, Christian Sorg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7538943536164f5bbc50b3e232ccf919
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spelling	oai:doaj.org-article:7538943536164f5bbc50b3e232ccf9192021-12-02T15:53:46ZDecreased amygdala volume in adults after premature birth10.1038/s41598-021-84906-22045-2322https://doaj.org/article/7538943536164f5bbc50b3e232ccf9192021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84906-2https://doaj.org/toc/2045-2322Abstract Premature-born infants have impaired amygdala structure, presumably due to increased stress levels of premature birth mediated by the amygdala. However, accounting for lifelong plasticity of amygdala, it is unclear whether such structural changes persist into adulthood. To address this problem, we stated the following questions: first, are whole amygdala volumes reduced in premature-born adults? And second, as adult anxiety traits are often increased after prematurity and linked with amygdala structure, are alterations in amygdala associated with adults’ anxiety traits after premature birth? We addressed these questions by automated amygdala segmentation of MRI volumes in 101 very premature-born adults (< 32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls at 26 years of age of a prospectively and longitudinally collected cohort. We found significantly lower whole amygdala volumes in premature-born adults. While premature-born adults had significantly higher T score for avoidant personality reflecting increased social anxiety trait, this trait was not correlated with amygdala volume alterations. Results demonstrate reduced amygdala volumes in premature born adults. Data suggest lasting effects of prematurity on amygdala structure.Benita Schmitz-KoepJuliana ZimmermannAurore MenegauxRachel NuttallJosef G. BäumlSebastian C. SchneiderMarcel DaamenHenning BoeckerClaus ZimmerDieter WolkePeter BartmannDennis M. HedderichChristian SorgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Benita Schmitz-Koep Juliana Zimmermann Aurore Menegaux Rachel Nuttall Josef G. Bäuml Sebastian C. Schneider Marcel Daamen Henning Boecker Claus Zimmer Dieter Wolke Peter Bartmann Dennis M. Hedderich Christian Sorg Decreased amygdala volume in adults after premature birth
description	Abstract Premature-born infants have impaired amygdala structure, presumably due to increased stress levels of premature birth mediated by the amygdala. However, accounting for lifelong plasticity of amygdala, it is unclear whether such structural changes persist into adulthood. To address this problem, we stated the following questions: first, are whole amygdala volumes reduced in premature-born adults? And second, as adult anxiety traits are often increased after prematurity and linked with amygdala structure, are alterations in amygdala associated with adults’ anxiety traits after premature birth? We addressed these questions by automated amygdala segmentation of MRI volumes in 101 very premature-born adults (< 32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls at 26 years of age of a prospectively and longitudinally collected cohort. We found significantly lower whole amygdala volumes in premature-born adults. While premature-born adults had significantly higher T score for avoidant personality reflecting increased social anxiety trait, this trait was not correlated with amygdala volume alterations. Results demonstrate reduced amygdala volumes in premature born adults. Data suggest lasting effects of prematurity on amygdala structure.
format	article
author	Benita Schmitz-Koep Juliana Zimmermann Aurore Menegaux Rachel Nuttall Josef G. Bäuml Sebastian C. Schneider Marcel Daamen Henning Boecker Claus Zimmer Dieter Wolke Peter Bartmann Dennis M. Hedderich Christian Sorg
author_facet	Benita Schmitz-Koep Juliana Zimmermann Aurore Menegaux Rachel Nuttall Josef G. Bäuml Sebastian C. Schneider Marcel Daamen Henning Boecker Claus Zimmer Dieter Wolke Peter Bartmann Dennis M. Hedderich Christian Sorg
author_sort	Benita Schmitz-Koep
title	Decreased amygdala volume in adults after premature birth
title_short	Decreased amygdala volume in adults after premature birth
title_full	Decreased amygdala volume in adults after premature birth
title_fullStr	Decreased amygdala volume in adults after premature birth
title_full_unstemmed	Decreased amygdala volume in adults after premature birth
title_sort	decreased amygdala volume in adults after premature birth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7538943536164f5bbc50b3e232ccf919
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Decreased amygdala volume in adults after premature birth

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