Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012

Abstract Purpose Many smaller studies have previously shown a significant association between thyroid autoantibody induced hypothyroidism and lower serum vitamin D levels. However, these finding have not been confirmed by large-scale studies. In this study, we evaluated the relationship between hypo...

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Autores principales:	Sandeep Appunni, Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Raees Tonse, Emir Veledar, Peter McGranaghan
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Hypothyroidism Low vitamin D Autoimmune Thyroid peroxidase Thyroglobulin Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/7539e95837ef4bfa9d3e3fabd5712d42
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spelling	oai:doaj.org-article:7539e95837ef4bfa9d3e3fabd5712d422021-11-14T12:05:32ZAssociation between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–201210.1186/s12902-021-00897-11472-6823https://doaj.org/article/7539e95837ef4bfa9d3e3fabd5712d422021-11-01T00:00:00Zhttps://doi.org/10.1186/s12902-021-00897-1https://doaj.org/toc/1472-6823Abstract Purpose Many smaller studies have previously shown a significant association between thyroid autoantibody induced hypothyroidism and lower serum vitamin D levels. However, these finding have not been confirmed by large-scale studies. In this study, we evaluated the relationship between hypothyroidism and vitamin D levels using a large population-based data. Methods For this study, we used National Health and Nutrition Examination Survey (NHANES) during the years 2007–2012. We categorized participants into three clinically relevant categories based on vitamin D levels: optimal, intermediate and deficient. Participants were also split into hypothyroid and hyperthyroid. Weighted multivariable logistic regression analyses were used to calculate the odds of being hypothyroid based on vitamin D status. Results A total of 7943 participants were included in this study, of which 614 (7.7%) were having hypothyroidism. Nearly 25.6% of hypothyroid patients had vitamin D deficiency, compared to 20.6% among normal controls. Adjusted logistic regression analyses showed that the odds of developing hypothyroidism were significantly higher among patients with intermediate (adjusted odds ratio [aOR], 1.7, 95% CI: 1.5–1.8) and deficient levels of vitamin D (aOR, 1.6, 95% CI: 1.4–1.9). Conclusion Low vitamin D levels are associated with autoimmune hypothyroidism. Healthcare initiatives such as mass vitamin D deficiency screening among at-risk population could significantly decrease the risk for hypothyroidism in the long-term.Sandeep AppunniMuni RubensVenkataraghavan RamamoorthyAnshul SaxenaRaees TonseEmir VeledarPeter McGranaghanBMCarticleHypothyroidismLow vitamin DAutoimmuneThyroid peroxidaseThyroglobulinDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENBMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hypothyroidism Low vitamin D Autoimmune Thyroid peroxidase Thyroglobulin Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Hypothyroidism Low vitamin D Autoimmune Thyroid peroxidase Thyroglobulin Diseases of the endocrine glands. Clinical endocrinology RC648-665 Sandeep Appunni Muni Rubens Venkataraghavan Ramamoorthy Anshul Saxena Raees Tonse Emir Veledar Peter McGranaghan Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
description	Abstract Purpose Many smaller studies have previously shown a significant association between thyroid autoantibody induced hypothyroidism and lower serum vitamin D levels. However, these finding have not been confirmed by large-scale studies. In this study, we evaluated the relationship between hypothyroidism and vitamin D levels using a large population-based data. Methods For this study, we used National Health and Nutrition Examination Survey (NHANES) during the years 2007–2012. We categorized participants into three clinically relevant categories based on vitamin D levels: optimal, intermediate and deficient. Participants were also split into hypothyroid and hyperthyroid. Weighted multivariable logistic regression analyses were used to calculate the odds of being hypothyroid based on vitamin D status. Results A total of 7943 participants were included in this study, of which 614 (7.7%) were having hypothyroidism. Nearly 25.6% of hypothyroid patients had vitamin D deficiency, compared to 20.6% among normal controls. Adjusted logistic regression analyses showed that the odds of developing hypothyroidism were significantly higher among patients with intermediate (adjusted odds ratio [aOR], 1.7, 95% CI: 1.5–1.8) and deficient levels of vitamin D (aOR, 1.6, 95% CI: 1.4–1.9). Conclusion Low vitamin D levels are associated with autoimmune hypothyroidism. Healthcare initiatives such as mass vitamin D deficiency screening among at-risk population could significantly decrease the risk for hypothyroidism in the long-term.
format	article
author	Sandeep Appunni Muni Rubens Venkataraghavan Ramamoorthy Anshul Saxena Raees Tonse Emir Veledar Peter McGranaghan
author_facet	Sandeep Appunni Muni Rubens Venkataraghavan Ramamoorthy Anshul Saxena Raees Tonse Emir Veledar Peter McGranaghan
author_sort	Sandeep Appunni
title	Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
title_short	Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
title_full	Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
title_fullStr	Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
title_full_unstemmed	Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012
title_sort	association between vitamin d deficiency and hypothyroidism: results from the national health and nutrition examination survey (nhanes) 2007–2012
publisher	BMC
publishDate	2021
url	https://doaj.org/article/7539e95837ef4bfa9d3e3fabd5712d42
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Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007–2012

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