Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients
Abstract Major depressive disorder (MDD) is a prevalent psychiatric disorder, and exposure to stress is a robust risk factor for MDD. Clinical data and rodent models have indicated the negative impact of chronic exposure to stress-induced hormones like cortisol on brain volume, memory, and cell meta...
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Main Authors: | Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle Skime, Timothy Nelson, Daniel Hall-Flavin, Richard Weinshilboum, Fred H. Gage, Krishna C. Vadodaria |
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Format: | article |
Language: | EN |
Published: |
Nature Publishing Group
2021
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Online Access: | https://doaj.org/article/753b9b999f8c450c8e0472172f86f547 |
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