Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics

Abstract Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies....

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Autores principales:	Georgios Moros, Theodora Boutsikou, Charalambos Fotakis, Zoe Iliodromiti, Rozeta Sokou, Theodora Katsila, Theodoros Xanthos, Nicoletta Iacovidou, Panagiotis Zoumpoulakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/753d155d08a1469f8d78cd926ae97da7
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spelling	oai:doaj.org-article:753d155d08a1469f8d78cd926ae97da72021-12-02T14:37:08ZInsights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics10.1038/s41598-021-87323-72045-2322https://doaj.org/article/753d155d08a1469f8d78cd926ae97da72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87323-7https://doaj.org/toc/2045-2322Abstract Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) followed by pathway and enrichment analysis generated classification models and revealed significant metabolites that were associated with altered pathways. A clear association between maternal and cord blood altered metabolomic profile was evidenced in IUGR pregnancies. Increased levels of the amino acids alanine, leucine, valine, isoleucine and phenylalanine were prominent in IUGR pregnancies indicating a connection with impaired amino acid metabolism and transplacental flux. Tryptophan was individually connected with cord blood discrimination while 3-hydroxybutyrate assisted only maternal blood discrimination. Lower glycerol levels in IUGR samples ascribed to imbalance between gluconeogenesis and glycolysis pathways, suggesting poor glycolysis. The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance.Georgios MorosTheodora BoutsikouCharalambos FotakisZoe IliodromitiRozeta SokouTheodora KatsilaTheodoros XanthosNicoletta IacovidouPanagiotis ZoumpoulakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Georgios Moros Theodora Boutsikou Charalambos Fotakis Zoe Iliodromiti Rozeta Sokou Theodora Katsila Theodoros Xanthos Nicoletta Iacovidou Panagiotis Zoumpoulakis Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
description	Abstract Intrauterine growth restriction (IUGR) is a fetal adverse condition, ascribed by limited oxygen and nutrient supply from the mother to the fetus. Management of IUGR is an ongoing challenge because of its connection with increased fetal mortality, preterm delivery and postnatal pathologies. Untargeted nuclear magnetic resonance (1H NMR) metabolomics was applied in 84 umbilical cord blood and maternal blood samples obtained from 48 IUGR and 36 appropriate for gestational age (AGA) deliveries. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) followed by pathway and enrichment analysis generated classification models and revealed significant metabolites that were associated with altered pathways. A clear association between maternal and cord blood altered metabolomic profile was evidenced in IUGR pregnancies. Increased levels of the amino acids alanine, leucine, valine, isoleucine and phenylalanine were prominent in IUGR pregnancies indicating a connection with impaired amino acid metabolism and transplacental flux. Tryptophan was individually connected with cord blood discrimination while 3-hydroxybutyrate assisted only maternal blood discrimination. Lower glycerol levels in IUGR samples ascribed to imbalance between gluconeogenesis and glycolysis pathways, suggesting poor glycolysis. The elevated levels of branched chain amino acids (leucine, isoleucine and valine) in intrauterine growth restricted pregnancies were linked with increased insulin resistance.
format	article
author	Georgios Moros Theodora Boutsikou Charalambos Fotakis Zoe Iliodromiti Rozeta Sokou Theodora Katsila Theodoros Xanthos Nicoletta Iacovidou Panagiotis Zoumpoulakis
author_facet	Georgios Moros Theodora Boutsikou Charalambos Fotakis Zoe Iliodromiti Rozeta Sokou Theodora Katsila Theodoros Xanthos Nicoletta Iacovidou Panagiotis Zoumpoulakis
author_sort	Georgios Moros
title	Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
title_short	Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
title_full	Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
title_fullStr	Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
title_full_unstemmed	Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
title_sort	insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/753d155d08a1469f8d78cd926ae97da7
work_keys_str_mv	AT georgiosmoros insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT theodoraboutsikou insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT charalambosfotakis insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT zoeiliodromiti insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT rozetasokou insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT theodorakatsila insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT theodorosxanthos insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT nicolettaiacovidou insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics AT panagiotiszoumpoulakis insightsintointrauterinegrowthrestrictionbasedonmaternalandumbilicalcordbloodmetabolomics
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Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics

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