The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-...

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Autores principales:	Bing Liu, Oscar C. Salgado, Sangya Singh, Keli L. Hippen, Jason C. Maynard, Alma L. Burlingame, Lauren E. Ball, Bruce R. Blazar, Michael A. Farrar, Kristin A. Hogquist, Hai-Bin Ruan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/753e12c8c75848d7bf15336570926002
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spelling	oai:doaj.org-article:753e12c8c75848d7bf153365709260022021-12-02T14:39:17ZThe lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation10.1038/s41467-019-08300-32041-1723https://doaj.org/article/753e12c8c75848d7bf153365709260022019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08300-3https://doaj.org/toc/2041-1723The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity.Bing LiuOscar C. SalgadoSangya SinghKeli L. HippenJason C. MaynardAlma L. BurlingameLauren E. BallBruce R. BlazarMichael A. FarrarKristin A. HogquistHai-Bin RuanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bing Liu Oscar C. Salgado Sangya Singh Keli L. Hippen Jason C. Maynard Alma L. Burlingame Lauren E. Ball Bruce R. Blazar Michael A. Farrar Kristin A. Hogquist Hai-Bin Ruan The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
description	The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-specific deficiency of OGT leading to severe autoimmunity.
format	article
author	Bing Liu Oscar C. Salgado Sangya Singh Keli L. Hippen Jason C. Maynard Alma L. Burlingame Lauren E. Ball Bruce R. Blazar Michael A. Farrar Kristin A. Hogquist Hai-Bin Ruan
author_facet	Bing Liu Oscar C. Salgado Sangya Singh Keli L. Hippen Jason C. Maynard Alma L. Burlingame Lauren E. Ball Bruce R. Blazar Michael A. Farrar Kristin A. Hogquist Hai-Bin Ruan
author_sort	Bing Liu
title	The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
title_short	The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
title_full	The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
title_fullStr	The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
title_full_unstemmed	The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation
title_sort	lineage stability and suppressive program of regulatory t cells require protein o-glcnacylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/753e12c8c75848d7bf15336570926002
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The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

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