The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

The transcription factor Foxp3 and Stat5 modulate lineage stability and function of regulatory T (Treg) cells to promote immune homeostasis. Here the authors show that O-GlcNAcylation of Foxp3 and Stat5, mediated by O-GlcNAc transferase (OGT), is essential for Treg-mediate immune balance, with Treg-...

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Autores principales: Bing Liu, Oscar C. Salgado, Sangya Singh, Keli L. Hippen, Jason C. Maynard, Alma L. Burlingame, Lauren E. Ball, Bruce R. Blazar, Michael A. Farrar, Kristin A. Hogquist, Hai-Bin Ruan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/753e12c8c75848d7bf15336570926002
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