Production of human CAR-NK cells with lentiviral vectors and functional assessment in vitro

Summary: Although natural killer (NK) cells have become a promising immune effector cell for chimeric antigen receptor (CAR)-based therapy, generating human CAR-NK cells with high transgene efficiency has been challenging. In this protocol, we describe how to generate CAR-NK cells with transduction...

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Auteurs principaux: Ana L. Portillo, Richard Hogg, Ali A. Ashkar
Format: article
Langue:EN
Publié: Elsevier 2021
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Accès en ligne:https://doaj.org/article/7540abfaed4544eaa9ea2867d0c58adb
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