Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells

Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised transcription factors that are SE-associated, provid...

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Autores principales:	Bum-Kyu Lee, Yu jin Jang, Mijeong Kim, Lucy LeBlanc, Catherine Rhee, Jiwoon Lee, Samuel Beck, Wenwen Shen, Jonghwan Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7542d27cd2304f37a4ead0cec651eb99
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spelling	oai:doaj.org-article:7542d27cd2304f37a4ead0cec651eb992021-12-02T17:33:22ZSuper-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells10.1038/s41467-019-12720-62041-1723https://doaj.org/article/7542d27cd2304f37a4ead0cec651eb992019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12720-6https://doaj.org/toc/2041-1723Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised transcription factors that are SE-associated, providing insight into trophectoderm-specific regulatory networks.Bum-Kyu LeeYu jin JangMijeong KimLucy LeBlancCatherine RheeJiwoon LeeSamuel BeckWenwen ShenJonghwan KimNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bum-Kyu Lee Yu jin Jang Mijeong Kim Lucy LeBlanc Catherine Rhee Jiwoon Lee Samuel Beck Wenwen Shen Jonghwan Kim Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
description	Trophectoderm lineage development is essential for implantation, placentation, and healthy pregnancy. Here the authors map super-enhancers (SEs) in trophoblast stem cells and find both TE-specific master regulators and 150 previous uncharacterised transcription factors that are SE-associated, providing insight into trophectoderm-specific regulatory networks.
format	article
author	Bum-Kyu Lee Yu jin Jang Mijeong Kim Lucy LeBlanc Catherine Rhee Jiwoon Lee Samuel Beck Wenwen Shen Jonghwan Kim
author_facet	Bum-Kyu Lee Yu jin Jang Mijeong Kim Lucy LeBlanc Catherine Rhee Jiwoon Lee Samuel Beck Wenwen Shen Jonghwan Kim
author_sort	Bum-Kyu Lee
title	Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
title_short	Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
title_full	Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
title_fullStr	Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
title_full_unstemmed	Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
title_sort	super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7542d27cd2304f37a4ead0cec651eb99
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Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells

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