Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice

Abstract Antibodies have been explored extensively as a potential therapeutic for Alzheimer’s disease, where amyloid-β (Aβ) peptides and the tau protein deposit in patient brains. While the major focus of antibody-based therapy development was on Aβ, arguably with limited success in clinical trials,...

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Autores principales: Julia van der Hoven, Annika van Hummel, Magdalena Przybyla, Prita R. Asih, Mehul Gajwani, Astrid F. Feiten, Yazi D. Ke, Arne Ittner, Janet van Eersel, Lars M. Ittner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7542fd4f0b3143c8a94362ae7f8f1328
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