AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibitor olaparib in multiple mouse tumour models.
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Nature Portfolio
2019
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oai:doaj.org-article:7547983126794fc0a17cf1c4d462a2982021-12-02T16:57:33ZAZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity10.1038/s41467-019-12836-92041-1723https://doaj.org/article/7547983126794fc0a17cf1c4d462a2982019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12836-9https://doaj.org/toc/2041-1723DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibitor olaparib in multiple mouse tumour models.Jacqueline H. L. FokAntonio Ramos-MontoyaMercedes Vazquez-ChantadaPaul W. G. WijnhovenValeria FolliaNeil JamesPaul M. FarringtonAnkur KarmokarSophie E. WillisJonathan CairnsJenni NikkiläDavid BeattieGillian M. LamontM. Raymond V. FinlayJoanne WilsonAaron SmithLenka Oplustil O’ConnorStephanie LingStephen E. FawellMark J. O’ConnorSimon J. HollingsworthEmma DeanFrederick W. GoldbergBarry R. DaviesElaine B. CadoganNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jacqueline H. L. Fok Antonio Ramos-Montoya Mercedes Vazquez-Chantada Paul W. G. Wijnhoven Valeria Follia Neil James Paul M. Farrington Ankur Karmokar Sophie E. Willis Jonathan Cairns Jenni Nikkilä David Beattie Gillian M. Lamont M. Raymond V. Finlay Joanne Wilson Aaron Smith Lenka Oplustil O’Connor Stephanie Ling Stephen E. Fawell Mark J. O’Connor Simon J. Hollingsworth Emma Dean Frederick W. Goldberg Barry R. Davies Elaine B. Cadogan AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity |
| description |
DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibitor olaparib in multiple mouse tumour models. |
| format |
article |
| author |
Jacqueline H. L. Fok Antonio Ramos-Montoya Mercedes Vazquez-Chantada Paul W. G. Wijnhoven Valeria Follia Neil James Paul M. Farrington Ankur Karmokar Sophie E. Willis Jonathan Cairns Jenni Nikkilä David Beattie Gillian M. Lamont M. Raymond V. Finlay Joanne Wilson Aaron Smith Lenka Oplustil O’Connor Stephanie Ling Stephen E. Fawell Mark J. O’Connor Simon J. Hollingsworth Emma Dean Frederick W. Goldberg Barry R. Davies Elaine B. Cadogan |
| author_facet |
Jacqueline H. L. Fok Antonio Ramos-Montoya Mercedes Vazquez-Chantada Paul W. G. Wijnhoven Valeria Follia Neil James Paul M. Farrington Ankur Karmokar Sophie E. Willis Jonathan Cairns Jenni Nikkilä David Beattie Gillian M. Lamont M. Raymond V. Finlay Joanne Wilson Aaron Smith Lenka Oplustil O’Connor Stephanie Ling Stephen E. Fawell Mark J. O’Connor Simon J. Hollingsworth Emma Dean Frederick W. Goldberg Barry R. Davies Elaine B. Cadogan |
| author_sort |
Jacqueline H. L. Fok |
| title |
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity |
| title_short |
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity |
| title_full |
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity |
| title_fullStr |
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity |
| title_full_unstemmed |
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity |
| title_sort |
azd7648 is a potent and selective dna-pk inhibitor that enhances radiation, chemotherapy and olaparib activity |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7547983126794fc0a17cf1c4d462a298 |
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