c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

Innate lymphoid cells (ILC) are important immune cells for maintaining the gut homeostasis. Here the authors show that c-FLIP, an anti-apoptotic molecule, is important for the development of NKP46+ ILC1, including conventional natural killer (cNK) cells, and ILC3, with cNK being more critical for am...

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Autores principales: Ute Bank, Katrin Deiser, Carlos Plaza-Sirvent, Lisa Osbelt, Amelie Witte, Laura Knop, Rebecca Labrenz, Robert Jänsch, Felix Richter, Aindrila Biswas, Ana C. Zenclussen, Eric Vivier, Chiara Romagnani, Anja A. Kühl, Ildiko R. Dunay, Till Strowig, Ingo Schmitz, Thomas Schüler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/7549ed63c2784f1b83cff7637ceec760
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Sumario:Innate lymphoid cells (ILC) are important immune cells for maintaining the gut homeostasis. Here the authors show that c-FLIP, an anti-apoptotic molecule, is important for the development of NKP46+ ILC1, including conventional natural killer (cNK) cells, and ILC3, with cNK being more critical for ameliorating intestinal inflammation.

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