c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice

Innate lymphoid cells (ILC) are important immune cells for maintaining the gut homeostasis. Here the authors show that c-FLIP, an anti-apoptotic molecule, is important for the development of NKP46+ ILC1, including conventional natural killer (cNK) cells, and ILC3, with cNK being more critical for am...

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Autores principales: Ute Bank, Katrin Deiser, Carlos Plaza-Sirvent, Lisa Osbelt, Amelie Witte, Laura Knop, Rebecca Labrenz, Robert Jänsch, Felix Richter, Aindrila Biswas, Ana C. Zenclussen, Eric Vivier, Chiara Romagnani, Anja A. Kühl, Ildiko R. Dunay, Till Strowig, Ingo Schmitz, Thomas Schüler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7549ed63c2784f1b83cff7637ceec760
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spelling oai:doaj.org-article:7549ed63c2784f1b83cff7637ceec7602021-12-02T15:39:17Zc-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice10.1038/s41467-020-14782-32041-1723https://doaj.org/article/7549ed63c2784f1b83cff7637ceec7602020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14782-3https://doaj.org/toc/2041-1723Innate lymphoid cells (ILC) are important immune cells for maintaining the gut homeostasis. Here the authors show that c-FLIP, an anti-apoptotic molecule, is important for the development of NKP46+ ILC1, including conventional natural killer (cNK) cells, and ILC3, with cNK being more critical for ameliorating intestinal inflammation.Ute BankKatrin DeiserCarlos Plaza-SirventLisa OsbeltAmelie WitteLaura KnopRebecca LabrenzRobert JänschFelix RichterAindrila BiswasAna C. ZenclussenEric VivierChiara RomagnaniAnja A. KühlIldiko R. DunayTill StrowigIngo SchmitzThomas SchülerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ute Bank
Katrin Deiser
Carlos Plaza-Sirvent
Lisa Osbelt
Amelie Witte
Laura Knop
Rebecca Labrenz
Robert Jänsch
Felix Richter
Aindrila Biswas
Ana C. Zenclussen
Eric Vivier
Chiara Romagnani
Anja A. Kühl
Ildiko R. Dunay
Till Strowig
Ingo Schmitz
Thomas Schüler
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
description Innate lymphoid cells (ILC) are important immune cells for maintaining the gut homeostasis. Here the authors show that c-FLIP, an anti-apoptotic molecule, is important for the development of NKP46+ ILC1, including conventional natural killer (cNK) cells, and ILC3, with cNK being more critical for ameliorating intestinal inflammation.
format article
author Ute Bank
Katrin Deiser
Carlos Plaza-Sirvent
Lisa Osbelt
Amelie Witte
Laura Knop
Rebecca Labrenz
Robert Jänsch
Felix Richter
Aindrila Biswas
Ana C. Zenclussen
Eric Vivier
Chiara Romagnani
Anja A. Kühl
Ildiko R. Dunay
Till Strowig
Ingo Schmitz
Thomas Schüler
author_facet Ute Bank
Katrin Deiser
Carlos Plaza-Sirvent
Lisa Osbelt
Amelie Witte
Laura Knop
Rebecca Labrenz
Robert Jänsch
Felix Richter
Aindrila Biswas
Ana C. Zenclussen
Eric Vivier
Chiara Romagnani
Anja A. Kühl
Ildiko R. Dunay
Till Strowig
Ingo Schmitz
Thomas Schüler
author_sort Ute Bank
title c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
title_short c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
title_full c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
title_fullStr c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
title_full_unstemmed c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice
title_sort c-flip is crucial for il-7/il-15-dependent nkp46+ ilc development and protection from intestinal inflammation in mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7549ed63c2784f1b83cff7637ceec760
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