A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism

mRNA translation efficiency is regulated in response to stimuli. Here the authors employ mass spectrometry analysis of ribosome fractions and show that under hypoxia, oxygen-sensitive RNA binding proteins enhance the translation efficiency of glycolysis pathway transcripts.

Guardado en:

Detalles Bibliográficos
Autores principales:	J. J. David Ho, Nathan C. Balukoff, Phaedra R. Theodoridis, Miling Wang, Jonathan R. Krieger, Jonathan H. Schatz, Stephen Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/754a4b16d6cf4bd486c30441585007ea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:754a4b16d6cf4bd486c30441585007ea
record_format	dspace
spelling	oai:doaj.org-article:754a4b16d6cf4bd486c30441585007ea2021-12-02T14:47:36ZA network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism10.1038/s41467-020-16504-12041-1723https://doaj.org/article/754a4b16d6cf4bd486c30441585007ea2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16504-1https://doaj.org/toc/2041-1723mRNA translation efficiency is regulated in response to stimuli. Here the authors employ mass spectrometry analysis of ribosome fractions and show that under hypoxia, oxygen-sensitive RNA binding proteins enhance the translation efficiency of glycolysis pathway transcripts.J. J. David HoNathan C. BalukoffPhaedra R. TheodoridisMiling WangJonathan R. KriegerJonathan H. SchatzStephen LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. J. David Ho Nathan C. Balukoff Phaedra R. Theodoridis Miling Wang Jonathan R. Krieger Jonathan H. Schatz Stephen Lee A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
description	mRNA translation efficiency is regulated in response to stimuli. Here the authors employ mass spectrometry analysis of ribosome fractions and show that under hypoxia, oxygen-sensitive RNA binding proteins enhance the translation efficiency of glycolysis pathway transcripts.
format	article
author	J. J. David Ho Nathan C. Balukoff Phaedra R. Theodoridis Miling Wang Jonathan R. Krieger Jonathan H. Schatz Stephen Lee
author_facet	J. J. David Ho Nathan C. Balukoff Phaedra R. Theodoridis Miling Wang Jonathan R. Krieger Jonathan H. Schatz Stephen Lee
author_sort	J. J. David Ho
title	A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
title_short	A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
title_full	A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
title_fullStr	A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
title_full_unstemmed	A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
title_sort	network of rna-binding proteins controls translation efficiency to activate anaerobic metabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/754a4b16d6cf4bd486c30441585007ea
work_keys_str_mv	AT jjdavidho anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT nathancbalukoff anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT phaedrartheodoridis anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT milingwang anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT jonathanrkrieger anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT jonathanhschatz anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT stephenlee anetworkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT jjdavidho networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT nathancbalukoff networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT phaedrartheodoridis networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT milingwang networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT jonathanrkrieger networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT jonathanhschatz networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism AT stephenlee networkofrnabindingproteinscontrolstranslationefficiencytoactivateanaerobicmetabolism
_version_	1718389517605404672

A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism

Ejemplares similares