Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach

Cherie Strikwerda-Brown,1–3 Siddharth Ramanan,1–3 Muireann Irish1–3 1The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia; 2The University of Sydney, School of Psychology, Sydney, NSW, Australia; 3ARC Centre of Excellence in Cognition and its Disorde...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Strikwerda-Brown C, Ramanan S, Irish M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	prefrontal cortex social cognition mentalizing executive function dementia empathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/754cc49d06584b219b511a1b356dd18b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:754cc49d06584b219b511a1b356dd18b
record_format	dspace
spelling	oai:doaj.org-article:754cc49d06584b219b511a1b356dd18b2021-12-02T02:24:34ZNeurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach1178-2021https://doaj.org/article/754cc49d06584b219b511a1b356dd18b2019-02-01T00:00:00Zhttps://www.dovepress.com/neurocognitive-mechanisms-of-theory-of-mind-impairment-in-neurodegener-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Cherie Strikwerda-Brown,1–3 Siddharth Ramanan,1–3 Muireann Irish1–3 1The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia; 2The University of Sydney, School of Psychology, Sydney, NSW, Australia; 3ARC Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia Abstract: Much of human interaction is predicated upon our innate capacity to infer the thoughts, beliefs, emotions, and perspectives of others, in short, to possess a “theory of mind” (ToM). While the term has evolved considerably since its inception, ToM encompasses our unique ability to apprehend the mental states of others, enabling us to anticipate and predict subsequent behavior. From a developmental perspective, ToM has been a topic of keen research interest, with numerous studies seeking to explicate the origins of this fundamental capacity and its disruption in developmental disorders such as autism. The study of ToM at the opposite end of the lifespan, however, is paradoxically new born, emerging as a topic of interest in its own right comparatively recently. Here, we consider the unique insights afforded by studying ToM capacity in neurodegenerative disorders. Arguing from a novel, transdiagnostic perspective, we consider how ToM vulnerability reflects the progressive degradation of neural circuits specialized for an array of higher-order cognitive processes. This mechanistic approach enables us to consider the common and unique neurocognitive mechanisms that underpin ToM dysfunction across neurodegenerative disorders and for the first time examine its relation to behavioral disturbances across social, intimate, legal, and criminal settings. As such, we aim to provide a comprehensive overview of ToM research in neurodegeneration, the resultant challenges for family members, clinicians, and the legal profession, and future directions worthy of exploration. Keywords: prefrontal cortex, social cognition, mentalizing, executive function, dementia, empathyStrikwerda-Brown CRamanan SIrish MDove Medical Pressarticleprefrontal cortexsocial cognitionmentalizingexecutive functiondementiaempathyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 557-573 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	prefrontal cortex social cognition mentalizing executive function dementia empathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	prefrontal cortex social cognition mentalizing executive function dementia empathy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Strikwerda-Brown C Ramanan S Irish M Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
description	Cherie Strikwerda-Brown,1–3 Siddharth Ramanan,1–3 Muireann Irish1–3 1The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia; 2The University of Sydney, School of Psychology, Sydney, NSW, Australia; 3ARC Centre of Excellence in Cognition and its Disorders, Sydney, NSW, Australia Abstract: Much of human interaction is predicated upon our innate capacity to infer the thoughts, beliefs, emotions, and perspectives of others, in short, to possess a “theory of mind” (ToM). While the term has evolved considerably since its inception, ToM encompasses our unique ability to apprehend the mental states of others, enabling us to anticipate and predict subsequent behavior. From a developmental perspective, ToM has been a topic of keen research interest, with numerous studies seeking to explicate the origins of this fundamental capacity and its disruption in developmental disorders such as autism. The study of ToM at the opposite end of the lifespan, however, is paradoxically new born, emerging as a topic of interest in its own right comparatively recently. Here, we consider the unique insights afforded by studying ToM capacity in neurodegenerative disorders. Arguing from a novel, transdiagnostic perspective, we consider how ToM vulnerability reflects the progressive degradation of neural circuits specialized for an array of higher-order cognitive processes. This mechanistic approach enables us to consider the common and unique neurocognitive mechanisms that underpin ToM dysfunction across neurodegenerative disorders and for the first time examine its relation to behavioral disturbances across social, intimate, legal, and criminal settings. As such, we aim to provide a comprehensive overview of ToM research in neurodegeneration, the resultant challenges for family members, clinicians, and the legal profession, and future directions worthy of exploration. Keywords: prefrontal cortex, social cognition, mentalizing, executive function, dementia, empathy
format	article
author	Strikwerda-Brown C Ramanan S Irish M
author_facet	Strikwerda-Brown C Ramanan S Irish M
author_sort	Strikwerda-Brown C
title	Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
title_short	Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
title_full	Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
title_fullStr	Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
title_full_unstemmed	Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
title_sort	neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/754cc49d06584b219b511a1b356dd18b
work_keys_str_mv	AT strikwerdabrownc neurocognitivemechanismsoftheoryofmindimpairmentinneurodegenerationatransdiagnosticapproach AT ramanans neurocognitivemechanismsoftheoryofmindimpairmentinneurodegenerationatransdiagnosticapproach AT irishm neurocognitivemechanismsoftheoryofmindimpairmentinneurodegenerationatransdiagnosticapproach
_version_	1718402477348356096

Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach

Ejemplares similares