Activity Disease in SLE Patients Affected IFN-γ in the IGRA Results
Winni Maharani,1,2 Dwi Febni Ratnaningsih,3 Fitria Utami,3 Fajar Awalia Yulianto,4 Anneke Dewina,5 Laniyati Hamijoyo,5,6 Nur Atik5,7 1Department of Microbiology, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia; 2Biomedical Sciences Master Program, Faculty of Medicine, Padjadjaran...
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2020
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| Acceso en línea: | https://doaj.org/article/75546f101017407ba4e52b1f2b23909f |
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| Sumario: | Winni Maharani,1,2 Dwi Febni Ratnaningsih,3 Fitria Utami,3 Fajar Awalia Yulianto,4 Anneke Dewina,5 Laniyati Hamijoyo,5,6 Nur Atik5,7 1Department of Microbiology, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia; 2Biomedical Sciences Master Program, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; 3Immunology Laboratory, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; 4Department of Public Health, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia; 5Lupus Study Centre, Immunology Study Group, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia; 6Department of Internal Medicine, Faculty of Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung, Indonesia; 7Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Bandung, IndonesiaCorrespondence: Nur AtikDepartment of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Bandung, IndonesiaTel +62 812-8095-6825Email n.atik@unpad.ac.idPurpose: Highly active systemic lupus erythematosus (SLE) causes a high risk of tuberculosis (TB) infection in SLE patients in Indonesia, a country in which the disease, especially extrapulmonary TB, is endemic. Interferon (IFN)-γ releasing assay (IGRA) can detect latent or previous TB infection. This study sought to determine latent TB infection and levels of IFN-γ, a key player in various inflammation and autoimmune disease, in patients with SLE and relate findings to disease activity.Patients and Methods: This experimental study included 79 female subjects distributed into three groups of active SLE, quiescent SLE and healthy controls. We used SLE Disease Activity Index– 2000 (SLEDAI-2K) scores to stratify the subjects. Each group underwent IGRA testing using the QuantiFERON-TB Gold Plus kit.Results: We recruited 59 female patients with SLE. The patients had a median age and disease duration 30 and 5 years, respectively. Statistical analysis using the Kruskal–Wallis test showed that active condition, high SLEDAI-2K score and immunosuppressive therapies affect IGRA results. Specifically, healthy controls (n=20) were most likely to have negative IGRA results (67.09%), whilst 27.27% of active cases (n=33) and 3.85% of quiescent cases (n=26) had indeterminate results (p=0.02). The number of immunosuppressant therapies was significantly negatively correlated with IFN-γ (p=0.004). No difference in IFN-γ concentration was detected amongst the active and other groups (p> 0.05).Conclusion: High-activity SLE and immunosuppressive therapies cause dysregulation of the immune response, which, in turn, influences IGRA results. Thus, additional testing is necessary to detect TB infection in patients with SLE.Keywords: SLE, active, quiescent, IFN-γ, IGRA |
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