Viral Suppression of RIPK1-Mediated Signaling

ABSTRACT Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4,...

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Autores principales:	Darshika J. Udawatte, Alan L. Rothman
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	apoptosis inflammation innate immunity necroptosis receptor-interacting protein kinase signal transduction Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/75599a8648d2457eb1dada87cc3b1529
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spelling	oai:doaj.org-article:75599a8648d2457eb1dada87cc3b15292021-11-10T18:37:52ZViral Suppression of RIPK1-Mediated Signaling10.1128/mBio.01723-212150-7511https://doaj.org/article/75599a8648d2457eb1dada87cc3b15292021-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01723-21https://doaj.org/toc/2150-7511ABSTRACT Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein kinase (MAPK) and interferon regulatory factor 3/7 (IRF3/7) phosphorylation, and cell death via apoptosis and necroptosis. Both cell death and inflammatory responses play a major role in controlling virus infections. Therefore, viruses have evolved multifaceted mechanisms to exploit host immune responses by targeting RIPK1. This review focuses on the current understanding of RIPK1-mediated inflammatory and cell death pathways and multiple mechanisms by which viruses manipulate these pathways by targeting RIPK1. We also discuss gaps in our knowledge regarding RIPK1-mediated signaling pathways and highlight potential avenues for future research.Darshika J. UdawatteAlan L. RothmanAmerican Society for Microbiologyarticleapoptosisinflammationinnate immunitynecroptosisreceptor-interacting protein kinasesignal transductionMicrobiologyQR1-502ENmBio, Vol 12, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis inflammation innate immunity necroptosis receptor-interacting protein kinase signal transduction Microbiology QR1-502
spellingShingle	apoptosis inflammation innate immunity necroptosis receptor-interacting protein kinase signal transduction Microbiology QR1-502 Darshika J. Udawatte Alan L. Rothman Viral Suppression of RIPK1-Mediated Signaling
description	ABSTRACT Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) has emerged as a key upstream regulator of cell death and inflammation. RIPK1-mediated signaling governs the outcome of signaling pathways initiated by tumor necrosis factor receptor 1 (TNFR1), Toll-like receptor 3 (TLR3), TLR4, retinoic acid-inducible gene 1 (RIG-I)/melanoma differentiation-associated protein 5 (MDA-5), and Z-binding protein 1 (ZBP1) by signaling for NF-κB activation, mitogen-associated protein kinase (MAPK) and interferon regulatory factor 3/7 (IRF3/7) phosphorylation, and cell death via apoptosis and necroptosis. Both cell death and inflammatory responses play a major role in controlling virus infections. Therefore, viruses have evolved multifaceted mechanisms to exploit host immune responses by targeting RIPK1. This review focuses on the current understanding of RIPK1-mediated inflammatory and cell death pathways and multiple mechanisms by which viruses manipulate these pathways by targeting RIPK1. We also discuss gaps in our knowledge regarding RIPK1-mediated signaling pathways and highlight potential avenues for future research.
format	article
author	Darshika J. Udawatte Alan L. Rothman
author_facet	Darshika J. Udawatte Alan L. Rothman
author_sort	Darshika J. Udawatte
title	Viral Suppression of RIPK1-Mediated Signaling
title_short	Viral Suppression of RIPK1-Mediated Signaling
title_full	Viral Suppression of RIPK1-Mediated Signaling
title_fullStr	Viral Suppression of RIPK1-Mediated Signaling
title_full_unstemmed	Viral Suppression of RIPK1-Mediated Signaling
title_sort	viral suppression of ripk1-mediated signaling
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/75599a8648d2457eb1dada87cc3b1529
work_keys_str_mv	AT darshikajudawatte viralsuppressionofripk1mediatedsignaling AT alanlrothman viralsuppressionofripk1mediatedsignaling
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Viral Suppression of RIPK1-Mediated Signaling

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