Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

Abstract Ischemic skeletal muscle conditions are known to augment exercise‐induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise. However, the effects of aging on the BP response to ischemic exercise remain unclear. We, therefore, tested the...

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Autores principales:	Daisuke Hasegawa, Amane Hori, Yukiko Okamura, Reizo Baba, Kenichi Suijo, Masaki Mizuno, Jun Sugawara, Koji Kitatsuji, Hisayoshi Ogata, Kaoru Toda, Norio Hotta
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	acidosis exercise pressor reflex muscle mechanoreflex muscle metaboreflex postexercise muscle ischemia Physiology QP1-981
Acceso en línea:	https://doaj.org/article/755c07f846074d78a521fb797427df8e
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spelling	oai:doaj.org-article:755c07f846074d78a521fb797427df8e2021-11-27T15:48:30ZAging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans2051-817X10.14814/phy2.15125https://doaj.org/article/755c07f846074d78a521fb797427df8e2021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15125https://doaj.org/toc/2051-817XAbstract Ischemic skeletal muscle conditions are known to augment exercise‐induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise. However, the effects of aging on the BP response to ischemic exercise remain unclear. We, therefore, tested the hypothesis that aging enhances the BP response to rhythmic handgrip (RHG) exercise during postexercise muscle ischemia (PEMI). We divided the normotensive participants without cardiovascular diseases into three age groups: young (n = 26; age, 18–28 years), middle‐aged (n = 23; age, 35–59 years), and older adults (n = 23; age, 60–80 years). The participants performed RHG exercise with minimal effort for 1 min after rest with and without PEMI, which was induced by inflating a cuff on the upper arm just before the isometric handgrip exercise ended; the intensity was 30% of maximal voluntary contraction force. Under PEMI, the increase in diastolic BP (DBP) from rest to RHG exercise in the older adult group (Δ13 ± 2 mmHg) was significantly higher than that in the young (Δ5 ± 2 mmHg) and middle‐aged groups (Δ6 ± 1 mmHg), despite there being no significant difference between the groups in the DBP response from rest to RHG exercise without PEMI. Importantly, based on multiple regression analysis, age remained a significant independent determinant of both the SBP and DBP responses to RHG exercise during PEMI (p < 0.01). These findings indicate that aging enhances the pressor response to ischemic rhythmic exercise.Daisuke HasegawaAmane HoriYukiko OkamuraReizo BabaKenichi SuijoMasaki MizunoJun SugawaraKoji KitatsujiHisayoshi OgataKaoru TodaNorio HottaWileyarticleacidosisexercise pressor reflexmuscle mechanoreflexmuscle metaboreflexpostexercise muscle ischemiaPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 22, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acidosis exercise pressor reflex muscle mechanoreflex muscle metaboreflex postexercise muscle ischemia Physiology QP1-981
spellingShingle	acidosis exercise pressor reflex muscle mechanoreflex muscle metaboreflex postexercise muscle ischemia Physiology QP1-981 Daisuke Hasegawa Amane Hori Yukiko Okamura Reizo Baba Kenichi Suijo Masaki Mizuno Jun Sugawara Koji Kitatsuji Hisayoshi Ogata Kaoru Toda Norio Hotta Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
description	Abstract Ischemic skeletal muscle conditions are known to augment exercise‐induced increases in blood pressure (BP). Aging is also a factor that enhances the pressor response to exercise. However, the effects of aging on the BP response to ischemic exercise remain unclear. We, therefore, tested the hypothesis that aging enhances the BP response to rhythmic handgrip (RHG) exercise during postexercise muscle ischemia (PEMI). We divided the normotensive participants without cardiovascular diseases into three age groups: young (n = 26; age, 18–28 years), middle‐aged (n = 23; age, 35–59 years), and older adults (n = 23; age, 60–80 years). The participants performed RHG exercise with minimal effort for 1 min after rest with and without PEMI, which was induced by inflating a cuff on the upper arm just before the isometric handgrip exercise ended; the intensity was 30% of maximal voluntary contraction force. Under PEMI, the increase in diastolic BP (DBP) from rest to RHG exercise in the older adult group (Δ13 ± 2 mmHg) was significantly higher than that in the young (Δ5 ± 2 mmHg) and middle‐aged groups (Δ6 ± 1 mmHg), despite there being no significant difference between the groups in the DBP response from rest to RHG exercise without PEMI. Importantly, based on multiple regression analysis, age remained a significant independent determinant of both the SBP and DBP responses to RHG exercise during PEMI (p < 0.01). These findings indicate that aging enhances the pressor response to ischemic rhythmic exercise.
format	article
author	Daisuke Hasegawa Amane Hori Yukiko Okamura Reizo Baba Kenichi Suijo Masaki Mizuno Jun Sugawara Koji Kitatsuji Hisayoshi Ogata Kaoru Toda Norio Hotta
author_facet	Daisuke Hasegawa Amane Hori Yukiko Okamura Reizo Baba Kenichi Suijo Masaki Mizuno Jun Sugawara Koji Kitatsuji Hisayoshi Ogata Kaoru Toda Norio Hotta
author_sort	Daisuke Hasegawa
title	Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
title_short	Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
title_full	Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
title_fullStr	Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
title_full_unstemmed	Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
title_sort	aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/755c07f846074d78a521fb797427df8e
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Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

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