Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease

Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. However, it is unclear whether microbiota and metabolites have demonstrated changes at early PD due to the difficulties in diagnosis and identification of early PD in clinical practice. In a previous study, we...

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Autores principales:	Yaping Yan, Shuchao Ren, Yanchao Duan, Chenyu Lu, Yuyu Niu, Zhengbo Wang, Briauna Inglis, Weizhi Ji, Yun Zheng, Wei Si
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/755df831524046c7887d57638305af25
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spelling	oai:doaj.org-article:755df831524046c7887d57638305af252021-12-02T16:37:38ZGut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease10.1038/s41522-021-00242-32055-5008https://doaj.org/article/755df831524046c7887d57638305af252021-09-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00242-3https://doaj.org/toc/2055-5008Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. However, it is unclear whether microbiota and metabolites have demonstrated changes at early PD due to the difficulties in diagnosis and identification of early PD in clinical practice. In a previous study, we generated A53T transgenic monkeys with early Parkinson’s symptoms, including anxiety and cognitive impairment. Here we analyzed the gut microbiota by metagenomic sequencing and metabolites by targeted gas chromatography. The gut microbiota analysis showed that the A53T monkeys have higher degree of diversity in gut microbiota with significantly elevated Sybergistetes, Akkermansia, and Eggerthella lenta compared with control monkeys. Prevotella significantly decreased in A53T transgenic monkeys. Glyceric acid, L-Aspartic acid, and p-Hydroxyphenylacetic acid were significantly elevated, whereas Myristic acid and 3-Methylindole were significantly decreased in A53T monkeys. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (KO0131) and the oxidative phosphorylation reaction (KO2147) were significantly increased in metabolic pathways of A53T monkeys. Our study suggested that the transgenic A53T and α-syn aggregation may affect the intestine microbiota and metabolites of rhesus monkeys, and the identified five compositional different metabolites that are mainly associated with mitochondrial dysfunction may be related to the pathogenesis of PD.Yaping YanShuchao RenYanchao DuanChenyu LuYuyu NiuZhengbo WangBriauna InglisWeizhi JiYun ZhengWei SiNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Yaping Yan Shuchao Ren Yanchao Duan Chenyu Lu Yuyu Niu Zhengbo Wang Briauna Inglis Weizhi Ji Yun Zheng Wei Si Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
description	Abstract Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. However, it is unclear whether microbiota and metabolites have demonstrated changes at early PD due to the difficulties in diagnosis and identification of early PD in clinical practice. In a previous study, we generated A53T transgenic monkeys with early Parkinson’s symptoms, including anxiety and cognitive impairment. Here we analyzed the gut microbiota by metagenomic sequencing and metabolites by targeted gas chromatography. The gut microbiota analysis showed that the A53T monkeys have higher degree of diversity in gut microbiota with significantly elevated Sybergistetes, Akkermansia, and Eggerthella lenta compared with control monkeys. Prevotella significantly decreased in A53T transgenic monkeys. Glyceric acid, L-Aspartic acid, and p-Hydroxyphenylacetic acid were significantly elevated, whereas Myristic acid and 3-Methylindole were significantly decreased in A53T monkeys. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (KO0131) and the oxidative phosphorylation reaction (KO2147) were significantly increased in metabolic pathways of A53T monkeys. Our study suggested that the transgenic A53T and α-syn aggregation may affect the intestine microbiota and metabolites of rhesus monkeys, and the identified five compositional different metabolites that are mainly associated with mitochondrial dysfunction may be related to the pathogenesis of PD.
format	article
author	Yaping Yan Shuchao Ren Yanchao Duan Chenyu Lu Yuyu Niu Zhengbo Wang Briauna Inglis Weizhi Ji Yun Zheng Wei Si
author_facet	Yaping Yan Shuchao Ren Yanchao Duan Chenyu Lu Yuyu Niu Zhengbo Wang Briauna Inglis Weizhi Ji Yun Zheng Wei Si
author_sort	Yaping Yan
title	Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
title_short	Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
title_full	Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
title_fullStr	Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
title_full_unstemmed	Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease
title_sort	gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/755df831524046c7887d57638305af25
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Gut microbiota and metabolites of α-synuclein transgenic monkey models with early stage of Parkinson’s disease

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