Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility

Yu-Chih Lin,1 Liang-Yi Lin,2 Ming-Yi Gao,3 Yi-Ping Fang31Department of Environmental Engineering and Health, Yuanpei University, 2Institute of Environmental Engineering, National Chiao Tung University, 3Department of Biotechnology, Yuanpei University, Hsinchu, TaiwanAbstract: Mesoporous silica nanop...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lin YC, Lin LY, Gao MY, Fang YP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/755eade3787b4828beb1d6db2190b931
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:755eade3787b4828beb1d6db2190b931
record_format	dspace
spelling	oai:doaj.org-article:755eade3787b4828beb1d6db2190b9312021-12-02T04:52:24ZMesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility1176-91141178-2013https://doaj.org/article/755eade3787b4828beb1d6db2190b9312013-10-01T00:00:00Zhttp://www.dovepress.com/mesoporous-silica-nanoparticles-synthesized-from-liquid-crystal-displa-a14666https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yu-Chih Lin,1 Liang-Yi Lin,2 Ming-Yi Gao,3 Yi-Ping Fang31Department of Environmental Engineering and Health, Yuanpei University, 2Institute of Environmental Engineering, National Chiao Tung University, 3Department of Biotechnology, Yuanpei University, Hsinchu, TaiwanAbstract: Mesoporous silica nanoparticles (MSNs) were synthesized as a promising drug delivery carrier due to the large surface area and porous characteristics. Our previous study successfully recycled wastes from the liquid crystal display (LCD) industry as the silica precursor. In this study, we substantiated the possibility of applying this material as a drug carrier. MSNs synthesized from the extraction of wastes from the manufacture of LCD panels were characterized as having an average diameter of 100 nm, a surface area of 788 m2/g, a uniform pore size distribution of 3.8 nm, and a pore volume of up to 1.04 cm3/g. Methotrexate and camptothecin were entrapped in MSNs at about 33.88% and 75.12%, respectively. The cell viability assay demonstrated that MSNs at 1 µg/mL had no significant influence on human lung fibroblast (WI-38) cells or ovarian cancer (ES-2) cells. A lactate dehydrogenase assay also indicated no inflammation occurred. Moreover, a hemolytic erythrocyte test indicated that the dose range of <100 µg/mL showed that 5% of erythrocytes were affected. After exposure to biofluids, the ordered structure was slightly degraded. The results revealed that MSNs synthesized from extraction of wastes from the manufacture of LCD panels had a good entrapment capacity for hydrophobic drugs and controllable safety conditions; they may be applied as a drug delivery carrier.Keywords: mesoporous silica nanoparticles (MSNs), waste recycle, drug delivery carrier, safety, biocompatibilityLin YCLin LYGao MYFang YPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3833-3842 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lin YC Lin LY Gao MY Fang YP Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
description	Yu-Chih Lin,1 Liang-Yi Lin,2 Ming-Yi Gao,3 Yi-Ping Fang31Department of Environmental Engineering and Health, Yuanpei University, 2Institute of Environmental Engineering, National Chiao Tung University, 3Department of Biotechnology, Yuanpei University, Hsinchu, TaiwanAbstract: Mesoporous silica nanoparticles (MSNs) were synthesized as a promising drug delivery carrier due to the large surface area and porous characteristics. Our previous study successfully recycled wastes from the liquid crystal display (LCD) industry as the silica precursor. In this study, we substantiated the possibility of applying this material as a drug carrier. MSNs synthesized from the extraction of wastes from the manufacture of LCD panels were characterized as having an average diameter of 100 nm, a surface area of 788 m2/g, a uniform pore size distribution of 3.8 nm, and a pore volume of up to 1.04 cm3/g. Methotrexate and camptothecin were entrapped in MSNs at about 33.88% and 75.12%, respectively. The cell viability assay demonstrated that MSNs at 1 µg/mL had no significant influence on human lung fibroblast (WI-38) cells or ovarian cancer (ES-2) cells. A lactate dehydrogenase assay also indicated no inflammation occurred. Moreover, a hemolytic erythrocyte test indicated that the dose range of <100 µg/mL showed that 5% of erythrocytes were affected. After exposure to biofluids, the ordered structure was slightly degraded. The results revealed that MSNs synthesized from extraction of wastes from the manufacture of LCD panels had a good entrapment capacity for hydrophobic drugs and controllable safety conditions; they may be applied as a drug delivery carrier.Keywords: mesoporous silica nanoparticles (MSNs), waste recycle, drug delivery carrier, safety, biocompatibility
format	article
author	Lin YC Lin LY Gao MY Fang YP
author_facet	Lin YC Lin LY Gao MY Fang YP
author_sort	Lin YC
title	Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
title_short	Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
title_full	Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
title_fullStr	Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
title_full_unstemmed	Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
title_sort	mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/755eade3787b4828beb1d6db2190b931
work_keys_str_mv	AT linyc mesoporoussilicananoparticlessynthesizedfromliquidcrystaldisplaymanufacturingextractsasapotentialcandidateforadrugdeliverycarrierevaluationoftheirsafetyandbiocompatibility AT linly mesoporoussilicananoparticlessynthesizedfromliquidcrystaldisplaymanufacturingextractsasapotentialcandidateforadrugdeliverycarrierevaluationoftheirsafetyandbiocompatibility AT gaomy mesoporoussilicananoparticlessynthesizedfromliquidcrystaldisplaymanufacturingextractsasapotentialcandidateforadrugdeliverycarrierevaluationoftheirsafetyandbiocompatibility AT fangyp mesoporoussilicananoparticlessynthesizedfromliquidcrystaldisplaymanufacturingextractsasapotentialcandidateforadrugdeliverycarrierevaluationoftheirsafetyandbiocompatibility
_version_	1718401013794209792

Mesoporous silica nanoparticles synthesized from liquid crystal display manufacturing extracts as a potential candidate for a drug delivery carrier: evaluation of their safety and biocompatibility

Ejemplares similares