Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study

ABSTRACT Circulating osteo progenitor (COP) cells are a heterogeneous population of cells that circulate within the peripheral blood with characteristics of the bone marrow mesenchymal stem and progenitor pool. Little is known about the behavior of this cell population in humans. The aim of this stu...

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Autores principales:	Jack Feehan, Cassandra Smith, Nicholas Tripodi, Elizabeth Degabrielle, Ahmed Al Saedi, Sara Vogrin, Gustavo Duque, Itamar Levinger
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	STROMAL/STEM CELLS CELLS OF BONE OSTEOPOROSIS DISEASES AND DISORDERS OF/RELATED TO BONE AGING Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/755eea38a9dc432e8e89faf8bc615a51
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spelling	oai:doaj.org-article:755eea38a9dc432e8e89faf8bc615a512021-11-04T12:00:57ZHigher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study2473-403910.1002/jbm4.10561https://doaj.org/article/755eea38a9dc432e8e89faf8bc615a512021-11-01T00:00:00Zhttps://doi.org/10.1002/jbm4.10561https://doaj.org/toc/2473-4039ABSTRACT Circulating osteo progenitor (COP) cells are a heterogeneous population of cells that circulate within the peripheral blood with characteristics of the bone marrow mesenchymal stem and progenitor pool. Little is known about the behavior of this cell population in humans. The aim of this study was to identify whether a relationship exists between COP cells (as a percentage of the peripheral blood monocytic cells) and musculoskeletal morphometry and to identify if COP have potential clinical utility as a biomarker for osteoporosis. We recruited 57 older adults (median age: 69 years; IQR: 65, 75 years) living independently in the community and performed cross‐sectional analysis to identify associations between the percentage of COP cells and body composition parameters, and through receiver operating characteristic analysis, we evaluated their ability to act as a biomarker of osteoporosis. COP cells were moderately associated with whole‐body bone mineral density (BMD) (r = 0.323, p = 0.014) and bone mineral content (BMC) (r = 0.387, p = 0.003), neck of femur BMD (r = 0.473, p < 0.001), and BMC (r = 0.461, p < 0.001) as well as appendicular lean mass (ALM) (p = 0.038) and male sex (p = 0.044) in univariable analysis. In multivariable analysis controlling for age, gender, height, and weight, COP cells remained strongly associated with neck of femur BMD (p = 0.001) and content (p = 0.003). COP cells were also a good predictor of osteoporosis (dual‐energy X‐ray absorptiometry [DXA] T‐score < −2.5) at the neck of femur (cutoff: 0.4%; sensitivity: 100%; specificity 79%) and total body (cutoff: 0.35%; sensitivity: 80%; specificity: 81%). This study shows strong relationships between bone parameters and COP cell number and male sex. They also have potential as a biomarker of osteoporosis, which may provide a new tool for advanced detection and screening in clinical settings. Future larger evaluation studies should verify the cutoffs for biomarker use, and further explore the relationship between COP cells and muscle. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.Jack FeehanCassandra SmithNicholas TripodiElizabeth DegabrielleAhmed Al SaediSara VogrinGustavo DuqueItamar LevingerWileyarticleSTROMAL/STEM CELLSCELLS OF BONEOSTEOPOROSISDISEASES AND DISORDERS OF/RELATED TO BONEAGINGOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJBMR Plus, Vol 5, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	STROMAL/STEM CELLS CELLS OF BONE OSTEOPOROSIS DISEASES AND DISORDERS OF/RELATED TO BONE AGING Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	STROMAL/STEM CELLS CELLS OF BONE OSTEOPOROSIS DISEASES AND DISORDERS OF/RELATED TO BONE AGING Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935 Jack Feehan Cassandra Smith Nicholas Tripodi Elizabeth Degabrielle Ahmed Al Saedi Sara Vogrin Gustavo Duque Itamar Levinger Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
description	ABSTRACT Circulating osteo progenitor (COP) cells are a heterogeneous population of cells that circulate within the peripheral blood with characteristics of the bone marrow mesenchymal stem and progenitor pool. Little is known about the behavior of this cell population in humans. The aim of this study was to identify whether a relationship exists between COP cells (as a percentage of the peripheral blood monocytic cells) and musculoskeletal morphometry and to identify if COP have potential clinical utility as a biomarker for osteoporosis. We recruited 57 older adults (median age: 69 years; IQR: 65, 75 years) living independently in the community and performed cross‐sectional analysis to identify associations between the percentage of COP cells and body composition parameters, and through receiver operating characteristic analysis, we evaluated their ability to act as a biomarker of osteoporosis. COP cells were moderately associated with whole‐body bone mineral density (BMD) (r = 0.323, p = 0.014) and bone mineral content (BMC) (r = 0.387, p = 0.003), neck of femur BMD (r = 0.473, p < 0.001), and BMC (r = 0.461, p < 0.001) as well as appendicular lean mass (ALM) (p = 0.038) and male sex (p = 0.044) in univariable analysis. In multivariable analysis controlling for age, gender, height, and weight, COP cells remained strongly associated with neck of femur BMD (p = 0.001) and content (p = 0.003). COP cells were also a good predictor of osteoporosis (dual‐energy X‐ray absorptiometry [DXA] T‐score < −2.5) at the neck of femur (cutoff: 0.4%; sensitivity: 100%; specificity 79%) and total body (cutoff: 0.35%; sensitivity: 80%; specificity: 81%). This study shows strong relationships between bone parameters and COP cell number and male sex. They also have potential as a biomarker of osteoporosis, which may provide a new tool for advanced detection and screening in clinical settings. Future larger evaluation studies should verify the cutoffs for biomarker use, and further explore the relationship between COP cells and muscle. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
format	article
author	Jack Feehan Cassandra Smith Nicholas Tripodi Elizabeth Degabrielle Ahmed Al Saedi Sara Vogrin Gustavo Duque Itamar Levinger
author_facet	Jack Feehan Cassandra Smith Nicholas Tripodi Elizabeth Degabrielle Ahmed Al Saedi Sara Vogrin Gustavo Duque Itamar Levinger
author_sort	Jack Feehan
title	Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
title_short	Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
title_full	Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
title_fullStr	Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
title_full_unstemmed	Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
title_sort	higher levels of circulating osteoprogenitor cells are associated with higher bone mineral density and lean mass in older adults: a cross‐sectional study
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/755eea38a9dc432e8e89faf8bc615a51
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Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study

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