An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus

Studies comparing organized (O) and unresolved/disorganized (UD) attachment have consistently shown structural and functional brain abnormalities, although whether and how attachment patterns may affect resting state functional connectivity (RSFC) is still little characterized. Here, we investigated...

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Autores principales:	Gianluca Cruciani, Maddalena Boccia, Vittorio Lingiardi, Guido Giovanardi, Pietro Zingaretti, Grazia Fernanda Spitoni
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fMRI organized attachment unresolved attachment adult attachment resting-state functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/755ef0cb23744aadbff64f866638634a
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spelling	oai:doaj.org-article:755ef0cb23744aadbff64f866638634a2021-11-25T16:59:18ZAn Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus10.3390/brainsci111115392076-3425https://doaj.org/article/755ef0cb23744aadbff64f866638634a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1539https://doaj.org/toc/2076-3425Studies comparing organized (O) and unresolved/disorganized (UD) attachment have consistently shown structural and functional brain abnormalities, although whether and how attachment patterns may affect resting state functional connectivity (RSFC) is still little characterized. Here, we investigated RSFC of temporal and limbic regions of interest for UD attachment. Participants’ attachment was classified via the Adult Attachment Interview, and all participants underwent clinical assessment. Functional magnetic resonance imaging data were collected from 11 UD individuals and seven matched O participants during rest. A seed-to-voxel analysis was performed, including the anterior and the posterior cingulate cortex, the bilateral insula, amygdala and hippocampus as seed regions. No group differences in the clinical scales emerged. Compared to O, the UD group showed lower RSFC between the left amygdala and the left cerebellum (lobules VIII), and lower functional coupling between the right hippocampus and the posterior portion of the right middle temporal gyrus. Moreover, UD participants showed higher RSFC between the right amygdala and the anterior cingulate cortex. Our findings suggest RSFC alterations in regions associated with encoding of salient events, emotion processing, memories retrieval and self-referential processing in UD participants, highlighting the potential role of attachment experiences in shaping brain abnormalities also in non-clinical UD individuals.Gianluca CrucianiMaddalena BocciaVittorio LingiardiGuido GiovanardiPietro ZingarettiGrazia Fernanda SpitoniMDPI AGarticlefMRIorganized attachmentunresolved attachmentadult attachmentresting-state functional connectivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1539, p 1539 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fMRI organized attachment unresolved attachment adult attachment resting-state functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	fMRI organized attachment unresolved attachment adult attachment resting-state functional connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Gianluca Cruciani Maddalena Boccia Vittorio Lingiardi Guido Giovanardi Pietro Zingaretti Grazia Fernanda Spitoni An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus
description	Studies comparing organized (O) and unresolved/disorganized (UD) attachment have consistently shown structural and functional brain abnormalities, although whether and how attachment patterns may affect resting state functional connectivity (RSFC) is still little characterized. Here, we investigated RSFC of temporal and limbic regions of interest for UD attachment. Participants’ attachment was classified via the Adult Attachment Interview, and all participants underwent clinical assessment. Functional magnetic resonance imaging data were collected from 11 UD individuals and seven matched O participants during rest. A seed-to-voxel analysis was performed, including the anterior and the posterior cingulate cortex, the bilateral insula, amygdala and hippocampus as seed regions. No group differences in the clinical scales emerged. Compared to O, the UD group showed lower RSFC between the left amygdala and the left cerebellum (lobules VIII), and lower functional coupling between the right hippocampus and the posterior portion of the right middle temporal gyrus. Moreover, UD participants showed higher RSFC between the right amygdala and the anterior cingulate cortex. Our findings suggest RSFC alterations in regions associated with encoding of salient events, emotion processing, memories retrieval and self-referential processing in UD participants, highlighting the potential role of attachment experiences in shaping brain abnormalities also in non-clinical UD individuals.
format	article
author	Gianluca Cruciani Maddalena Boccia Vittorio Lingiardi Guido Giovanardi Pietro Zingaretti Grazia Fernanda Spitoni
author_facet	Gianluca Cruciani Maddalena Boccia Vittorio Lingiardi Guido Giovanardi Pietro Zingaretti Grazia Fernanda Spitoni
author_sort	Gianluca Cruciani
title	An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus
title_short	An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus
title_full	An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus
title_fullStr	An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus
title_full_unstemmed	An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus
title_sort	exploratory study on resting-state functional connectivity in individuals with disorganized attachment: evidence for key regions in amygdala and hippocampus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/755ef0cb23744aadbff64f866638634a
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An Exploratory Study on Resting-State Functional Connectivity in Individuals with Disorganized Attachment: Evidence for Key Regions in Amygdala and Hippocampus

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