Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.

Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets.

Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic consequences of n-3 PUFA depletion in the liver are poorly understood. We have reproduced a drastic drop in n-3 PUFA among hepatic...

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Autores principales: Barbara D Pachikian, Ahmed Essaghir, Jean-Baptiste Demoulin, Audrey M Neyrinck, Emilie Catry, Fabienne C De Backer, Nicolas Dejeans, Evelyne M Dewulf, Florence M Sohet, Laurence Portois, Louise Deldicque, Olivier Molendi-Coste, Isabelle A Leclercq, Marc Francaux, Yvon A Carpentier, Fabienne Foufelle, Giulio G Muccioli, Patrice D Cani, Nathalie M Delzenne
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/75626a5b5bac47a482041ccc4a173823
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