Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.

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Autores principales:	Benedikt Strunz, Julia Hengst, Katja Deterding, Michael P. Manns, Markus Cornberg, Hans-Gustaf Ljunggren, Heiner Wedemeyer, Niklas K. Björkström
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7563551b3be94ca4b9ea985c35f676c8
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spelling	oai:doaj.org-article:7563551b3be94ca4b9ea985c35f676c82021-12-02T16:56:57ZChronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity10.1038/s41467-018-04685-92041-1723https://doaj.org/article/7563551b3be94ca4b9ea985c35f676c82018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04685-9https://doaj.org/toc/2041-1723Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.Benedikt StrunzJulia HengstKatja DeterdingMichael P. MannsMarkus CornbergHans-Gustaf LjunggrenHeiner WedemeyerNiklas K. BjörkströmNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benedikt Strunz Julia Hengst Katja Deterding Michael P. Manns Markus Cornberg Hans-Gustaf Ljunggren Heiner Wedemeyer Niklas K. Björkström Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
description	Natural killer (NK) cells are important immune cells for mediating antiviral immunity. Here the authors show that chronic hepatitis C virus infection in human can imprint lasting functional phenotypes in NK cells to increase their inter-individual but decrease intra-individual diversity.
format	article
author	Benedikt Strunz Julia Hengst Katja Deterding Michael P. Manns Markus Cornberg Hans-Gustaf Ljunggren Heiner Wedemeyer Niklas K. Björkström
author_facet	Benedikt Strunz Julia Hengst Katja Deterding Michael P. Manns Markus Cornberg Hans-Gustaf Ljunggren Heiner Wedemeyer Niklas K. Björkström
author_sort	Benedikt Strunz
title	Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
title_short	Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
title_full	Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
title_fullStr	Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
title_full_unstemmed	Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity
title_sort	chronic hepatitis c virus infection irreversibly impacts human natural killer cell repertoire diversity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7563551b3be94ca4b9ea985c35f676c8
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Chronic hepatitis C virus infection irreversibly impacts human natural killer cell repertoire diversity

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