Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

Hypersensitivity of BRCA2 deficient cells to rosemary extract explained by weak PARP inhibitory activity

Abstract Rosemary extract is used in food additives and traditional medicine and has been observed to contain anti-tumor activity. In this study, rosemary extract is hypothesized to induce synthetic lethality in BRCA2 deficient cells by PARP inhibition. Chinese hamster lung V79 cells and its mutant...

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Autores principales: Cathy Su, Jeffrey P. Gius, Julia Van Steenberg, Alexis H. Haskins, Kazuki Heishima, Chisato Omata, Masahiro Iwayama, Mami Murakami, Takashi Mori, Kohji Maruo, Takamitsu A. Kato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7565a82dd66f49b1a36dd312937e9dcc
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