Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings

Background: It is unclear whether pigmented Spitz and Reed nevi are distinct morphologic entities or part of the spectrum of Spitz nevi. Methods: In a retrospective observational study we analyzed dermatopathologic slides of 22 cases with clinical and dermatoscopic features indicative of pigment...

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Autores principales:	Michael Bär, Philipp Tschandl, Harald Kittler
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2012
Materias:	pigmented Spitz nevus Reed nevus Spitz cells dermatoscopy histopathology melanocytic nevus Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/75671ac700df4ff5b58a8711ddf741bd
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spelling	oai:doaj.org-article:75671ac700df4ff5b58a8711ddf741bd2021-11-17T08:33:18ZDifferentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings10.5826/dpc.0201a032160-9381https://doaj.org/article/75671ac700df4ff5b58a8711ddf741bd2012-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/995https://doaj.org/toc/2160-9381 Background: It is unclear whether pigmented Spitz and Reed nevi are distinct morphologic entities or part of the spectrum of Spitz nevi. Methods: In a retrospective observational study we analyzed dermatopathologic slides of 22 cases with clinical and dermatoscopic features indicative of pigmented Spitz or Reed nevus in a blinded fashion according to predefined criteria and subsequently correlated dermatopathologic with clinical and dermatoscopic findings. Results: We differentiated pigmented Spitz and Reed nevus dermatopathologically by their capacity of melanin production and a vertical versus horizontal growth pattern. Based on histopathology 20 nevi (91%) could be reliably diagnosed as Reed nevus (68%, n = 15) or as pigmented Spitz nevus (23%, n = 5). In two cases (9%, n = 2) it was not possible to make a clear distinction from a dermatopathologic point of view. Dermatopathologic-dermatoscopic correlation showed that Reed nevi were characterized by a dermatoscopic pattern of peripheral radial lines or pseudopods (fascicular growth pattern), whereas pigmented Spitz nevi were typified by a pattern consisting of clods (nested growth pattern). “Spitz cells” (large epithelioid melanocytes) were more commonly found in Spitz nevi (100%, n = 5) but were also present in Reed nevi (n=6, 40%). Spindle cells were found in both types of nevi. Conclusions: Pigmented Spitz and Reed nevi can be reliably distinguished based on their dermatopathologic and dermatoscopic patterns. The specific dermatopathologic patterns of pigmented Spitz and Reed nevi correspond well to their dermatoscopic patterns. The presence of “Spitz cells” or spindle cells should not be regarded as the decisive criterion to differentiate between these two entities. Michael BärPhilipp TschandlHarald KittlerMattioli1885articlepigmented Spitz nevusReed nevusSpitz cellsdermatoscopyhistopathologymelanocytic nevusDermatologyRL1-803ENDermatology Practical & Conceptual (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	pigmented Spitz nevus Reed nevus Spitz cells dermatoscopy histopathology melanocytic nevus Dermatology RL1-803
spellingShingle	pigmented Spitz nevus Reed nevus Spitz cells dermatoscopy histopathology melanocytic nevus Dermatology RL1-803 Michael Bär Philipp Tschandl Harald Kittler Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings
description	Background: It is unclear whether pigmented Spitz and Reed nevi are distinct morphologic entities or part of the spectrum of Spitz nevi. Methods: In a retrospective observational study we analyzed dermatopathologic slides of 22 cases with clinical and dermatoscopic features indicative of pigmented Spitz or Reed nevus in a blinded fashion according to predefined criteria and subsequently correlated dermatopathologic with clinical and dermatoscopic findings. Results: We differentiated pigmented Spitz and Reed nevus dermatopathologically by their capacity of melanin production and a vertical versus horizontal growth pattern. Based on histopathology 20 nevi (91%) could be reliably diagnosed as Reed nevus (68%, n = 15) or as pigmented Spitz nevus (23%, n = 5). In two cases (9%, n = 2) it was not possible to make a clear distinction from a dermatopathologic point of view. Dermatopathologic-dermatoscopic correlation showed that Reed nevi were characterized by a dermatoscopic pattern of peripheral radial lines or pseudopods (fascicular growth pattern), whereas pigmented Spitz nevi were typified by a pattern consisting of clods (nested growth pattern). “Spitz cells” (large epithelioid melanocytes) were more commonly found in Spitz nevi (100%, n = 5) but were also present in Reed nevi (n=6, 40%). Spindle cells were found in both types of nevi. Conclusions: Pigmented Spitz and Reed nevi can be reliably distinguished based on their dermatopathologic and dermatoscopic patterns. The specific dermatopathologic patterns of pigmented Spitz and Reed nevi correspond well to their dermatoscopic patterns. The presence of “Spitz cells” or spindle cells should not be regarded as the decisive criterion to differentiate between these two entities.
format	article
author	Michael Bär Philipp Tschandl Harald Kittler
author_facet	Michael Bär Philipp Tschandl Harald Kittler
author_sort	Michael Bär
title	Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings
title_short	Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings
title_full	Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings
title_fullStr	Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings
title_full_unstemmed	Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings
title_sort	differentiation of pigmented spitz nevi and reed nevi by integration of dermatopathologic and dermatoscopic findings
publisher	Mattioli1885
publishDate	2012
url	https://doaj.org/article/75671ac700df4ff5b58a8711ddf741bd
work_keys_str_mv	AT michaelbar differentiationofpigmentedspitzneviandreednevibyintegrationofdermatopathologicanddermatoscopicfindings AT philipptschandl differentiationofpigmentedspitzneviandreednevibyintegrationofdermatopathologicanddermatoscopicfindings AT haraldkittler differentiationofpigmentedspitzneviandreednevibyintegrationofdermatopathologicanddermatoscopicfindings
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Differentiation of pigmented Spitz nevi and Reed nevi by integration of dermatopathologic and dermatoscopic findings

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