Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties

A technology for producing a nanocomposite based on the borsiloxane polymer and chemically unmodified fullerenes has been developed. Nanocomposites containing 0.001, 0.01, and 0.1 wt% fullerene molecules have been created. It has been shown that the nanocomposite with any content of fullerene molecu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sergey V. Gudkov, Alexander V. Simakin, Ruslan M. Sarimov, Alexander D. Kurilov, Denis N. Chausov
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fullerene borosiloxane bacteriostatic agents composite materials Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/756b0afd2f4244738825ceb5314ec930
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:756b0afd2f4244738825ceb5314ec930
record_format	dspace
spelling	oai:doaj.org-article:756b0afd2f4244738825ceb5314ec9302021-11-25T18:29:56ZNovel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties10.3390/nano111128042079-4991https://doaj.org/article/756b0afd2f4244738825ceb5314ec9302021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2804https://doaj.org/toc/2079-4991A technology for producing a nanocomposite based on the borsiloxane polymer and chemically unmodified fullerenes has been developed. Nanocomposites containing 0.001, 0.01, and 0.1 wt% fullerene molecules have been created. It has been shown that the nanocomposite with any content of fullerene molecules did not lose the main rheological properties of borsiloxane and is capable of structural self-healing. The resulting nanomaterial is capable of generating reactive oxygen species (ROS) such as hydrogen peroxide and hydroxyl radicals in light. The rate of ROS generation increases with an increase in the concentration of fullerene molecules. In the absence of light, the nanocomposite exhibits antioxidant properties. The severity of antioxidant properties is also associated with the concentration of fullerene molecules in the polymer. It has been shown that the nanocomposite upon exposure to visible light leads to the formation of long-lived reactive protein species, and is also the reason for the appearance of such a key biomarker of oxidative stress as 8-oxoguanine in DNA. The intensity of the process increases with an increase in the concentration of fullerene molecules. In the dark, the polymer exhibits weak protective properties. It was found that under the action of light, the nanocomposite exhibits significant bacteriostatic properties, and the severity of these properties depends on the concentration of fullerene molecules. Moreover, it was found that bacterial cells adhere to the surfaces of the nanocomposite, and the nanocomposite can detach bacterial cells not only from the surfaces, but also from wetted substrates. The ability to capture bacterial cells is primarily associated with the properties of the polymer; they are weakly affected by both visible light and fullerene molecules. The nanocomposite is non-toxic to eukaryotic cells, the surface of the nanocomposite is suitable for eukaryotic cells for colonization. Due to the combination of self-healing properties, low cytotoxicity, and the presence of bacteriostatic properties, the nanocomposite can be used as a reusable dry disinfectant, as well as a material used in prosthetics.Sergey V. GudkovAlexander V. SimakinRuslan M. SarimovAlexander D. KurilovDenis N. ChausovMDPI AGarticlefullereneborosiloxanebacteriostatic agentscomposite materialsChemistryQD1-999ENNanomaterials, Vol 11, Iss 2804, p 2804 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fullerene borosiloxane bacteriostatic agents composite materials Chemistry QD1-999
spellingShingle	fullerene borosiloxane bacteriostatic agents composite materials Chemistry QD1-999 Sergey V. Gudkov Alexander V. Simakin Ruslan M. Sarimov Alexander D. Kurilov Denis N. Chausov Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties
description	A technology for producing a nanocomposite based on the borsiloxane polymer and chemically unmodified fullerenes has been developed. Nanocomposites containing 0.001, 0.01, and 0.1 wt% fullerene molecules have been created. It has been shown that the nanocomposite with any content of fullerene molecules did not lose the main rheological properties of borsiloxane and is capable of structural self-healing. The resulting nanomaterial is capable of generating reactive oxygen species (ROS) such as hydrogen peroxide and hydroxyl radicals in light. The rate of ROS generation increases with an increase in the concentration of fullerene molecules. In the absence of light, the nanocomposite exhibits antioxidant properties. The severity of antioxidant properties is also associated with the concentration of fullerene molecules in the polymer. It has been shown that the nanocomposite upon exposure to visible light leads to the formation of long-lived reactive protein species, and is also the reason for the appearance of such a key biomarker of oxidative stress as 8-oxoguanine in DNA. The intensity of the process increases with an increase in the concentration of fullerene molecules. In the dark, the polymer exhibits weak protective properties. It was found that under the action of light, the nanocomposite exhibits significant bacteriostatic properties, and the severity of these properties depends on the concentration of fullerene molecules. Moreover, it was found that bacterial cells adhere to the surfaces of the nanocomposite, and the nanocomposite can detach bacterial cells not only from the surfaces, but also from wetted substrates. The ability to capture bacterial cells is primarily associated with the properties of the polymer; they are weakly affected by both visible light and fullerene molecules. The nanocomposite is non-toxic to eukaryotic cells, the surface of the nanocomposite is suitable for eukaryotic cells for colonization. Due to the combination of self-healing properties, low cytotoxicity, and the presence of bacteriostatic properties, the nanocomposite can be used as a reusable dry disinfectant, as well as a material used in prosthetics.
format	article
author	Sergey V. Gudkov Alexander V. Simakin Ruslan M. Sarimov Alexander D. Kurilov Denis N. Chausov
author_facet	Sergey V. Gudkov Alexander V. Simakin Ruslan M. Sarimov Alexander D. Kurilov Denis N. Chausov
author_sort	Sergey V. Gudkov
title	Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties
title_short	Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties
title_full	Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties
title_fullStr	Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties
title_full_unstemmed	Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties
title_sort	novel biocompatible with animal cells composite material based on organosilicon polymers and fullerenes with light-induced bacteriostatic properties
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/756b0afd2f4244738825ceb5314ec930
work_keys_str_mv	AT sergeyvgudkov novelbiocompatiblewithanimalcellscompositematerialbasedonorganosiliconpolymersandfullereneswithlightinducedbacteriostaticproperties AT alexandervsimakin novelbiocompatiblewithanimalcellscompositematerialbasedonorganosiliconpolymersandfullereneswithlightinducedbacteriostaticproperties AT ruslanmsarimov novelbiocompatiblewithanimalcellscompositematerialbasedonorganosiliconpolymersandfullereneswithlightinducedbacteriostaticproperties AT alexanderdkurilov novelbiocompatiblewithanimalcellscompositematerialbasedonorganosiliconpolymersandfullereneswithlightinducedbacteriostaticproperties AT denisnchausov novelbiocompatiblewithanimalcellscompositematerialbasedonorganosiliconpolymersandfullereneswithlightinducedbacteriostaticproperties
_version_	1718411083120640000

Novel Biocompatible with Animal Cells Composite Material Based on Organosilicon Polymers and Fullerenes with Light-Induced Bacteriostatic Properties

Ejemplares similares