Vitamins as Possible Cancer Biomarkers: Significance and Limitations
The Western-style diet, which is common in developed countries and spreading into developing countries, is unbalanced in many respects. For instance, micronutrients (vitamins A, B complex, C, D, E, and K plus iron, zinc, selenium, and iodine) are generally depleted in Western food (causing what is k...
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2021
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oai:doaj.org-article:75736e5f2f8b45e7acdb5a216e9fa1742021-11-25T18:35:15ZVitamins as Possible Cancer Biomarkers: Significance and Limitations10.3390/nu131139142072-6643https://doaj.org/article/75736e5f2f8b45e7acdb5a216e9fa1742021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3914https://doaj.org/toc/2072-6643The Western-style diet, which is common in developed countries and spreading into developing countries, is unbalanced in many respects. For instance, micronutrients (vitamins A, B complex, C, D, E, and K plus iron, zinc, selenium, and iodine) are generally depleted in Western food (causing what is known as ‘hidden hunger’), whereas some others (such as phosphorus) are added beyond the daily allowance. This imbalance in micronutrients can induce cellular damage that can increase the risk of cancer. Interestingly, there is a large body of evidence suggesting a strong correlation between vitamin intake as well as vitamin blood concentrations with the occurrence of certain types of cancer. The direction of association between the concentration of a given vitamin and cancer risk is tumor specific. The present review summarized the literature regarding vitamins and cancer risk to assess whether these could be used as diagnostic or prognostic markers, thus confirming their potential as biomarkers. Despite many studies that highlight the importance of monitoring vitamin blood or tissue concentrations in cancer patients and demonstrate the link between vitamin intake and cancer risk, there is still an urgent need for more data to assess the effectiveness of vitamins as biomarkers in the context of cancer. Therefore, this review aims to provide a solid basis to support further studies on this promising topic.Sascha VenturelliChristian LeischnerThomas HellingMarkus BurkardLuigi MarongiuMDPI AGarticlevitamin Avitamin B complexvitamin Cvitamin Dvitamin Evitamin KNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3914, p 3914 (2021) |
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DOAJ |
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DOAJ |
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| topic |
vitamin A vitamin B complex vitamin C vitamin D vitamin E vitamin K Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
vitamin A vitamin B complex vitamin C vitamin D vitamin E vitamin K Nutrition. Foods and food supply TX341-641 Sascha Venturelli Christian Leischner Thomas Helling Markus Burkard Luigi Marongiu Vitamins as Possible Cancer Biomarkers: Significance and Limitations |
| description |
The Western-style diet, which is common in developed countries and spreading into developing countries, is unbalanced in many respects. For instance, micronutrients (vitamins A, B complex, C, D, E, and K plus iron, zinc, selenium, and iodine) are generally depleted in Western food (causing what is known as ‘hidden hunger’), whereas some others (such as phosphorus) are added beyond the daily allowance. This imbalance in micronutrients can induce cellular damage that can increase the risk of cancer. Interestingly, there is a large body of evidence suggesting a strong correlation between vitamin intake as well as vitamin blood concentrations with the occurrence of certain types of cancer. The direction of association between the concentration of a given vitamin and cancer risk is tumor specific. The present review summarized the literature regarding vitamins and cancer risk to assess whether these could be used as diagnostic or prognostic markers, thus confirming their potential as biomarkers. Despite many studies that highlight the importance of monitoring vitamin blood or tissue concentrations in cancer patients and demonstrate the link between vitamin intake and cancer risk, there is still an urgent need for more data to assess the effectiveness of vitamins as biomarkers in the context of cancer. Therefore, this review aims to provide a solid basis to support further studies on this promising topic. |
| format |
article |
| author |
Sascha Venturelli Christian Leischner Thomas Helling Markus Burkard Luigi Marongiu |
| author_facet |
Sascha Venturelli Christian Leischner Thomas Helling Markus Burkard Luigi Marongiu |
| author_sort |
Sascha Venturelli |
| title |
Vitamins as Possible Cancer Biomarkers: Significance and Limitations |
| title_short |
Vitamins as Possible Cancer Biomarkers: Significance and Limitations |
| title_full |
Vitamins as Possible Cancer Biomarkers: Significance and Limitations |
| title_fullStr |
Vitamins as Possible Cancer Biomarkers: Significance and Limitations |
| title_full_unstemmed |
Vitamins as Possible Cancer Biomarkers: Significance and Limitations |
| title_sort |
vitamins as possible cancer biomarkers: significance and limitations |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/75736e5f2f8b45e7acdb5a216e9fa174 |
| work_keys_str_mv |
AT saschaventurelli vitaminsaspossiblecancerbiomarkerssignificanceandlimitations AT christianleischner vitaminsaspossiblecancerbiomarkerssignificanceandlimitations AT thomashelling vitaminsaspossiblecancerbiomarkerssignificanceandlimitations AT markusburkard vitaminsaspossiblecancerbiomarkerssignificanceandlimitations AT luigimarongiu vitaminsaspossiblecancerbiomarkerssignificanceandlimitations |
| _version_ |
1718410960463462400 |