Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dorota Chudoba, Monika Jażdżewska, Katarzyna Łudzik, Sebastian Wołoszczuk, Ewa Juszyńska-Gałązka, Mikołaj Kościński
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	modified carbon nanotubes drug delivery doxorubicin kinetics of release drug release mechanism Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/7574409baeea423990a1bd4710909396
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7574409baeea423990a1bd4710909396
record_format	dspace
spelling	oai:doaj.org-article:7574409baeea423990a1bd47109093962021-11-11T17:25:13ZDescription of Release Process of Doxorubicin from Modified Carbon Nanotubes10.3390/ijms2221120031422-00671661-6596https://doaj.org/article/7574409baeea423990a1bd47109093962021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12003https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.Dorota ChudobaMonika JażdżewskaKatarzyna ŁudzikSebastian WołoszczukEwa Juszyńska-GałązkaMikołaj KościńskiMDPI AGarticlemodified carbon nanotubesdrug deliverydoxorubicinkinetics of releasedrug release mechanismBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12003, p 12003 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	modified carbon nanotubes drug delivery doxorubicin kinetics of release drug release mechanism Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	modified carbon nanotubes drug delivery doxorubicin kinetics of release drug release mechanism Biology (General) QH301-705.5 Chemistry QD1-999 Dorota Chudoba Monika Jażdżewska Katarzyna Łudzik Sebastian Wołoszczuk Ewa Juszyńska-Gałązka Mikołaj Kościński Description of Release Process of Doxorubicin from Modified Carbon Nanotubes
description	The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.
format	article
author	Dorota Chudoba Monika Jażdżewska Katarzyna Łudzik Sebastian Wołoszczuk Ewa Juszyńska-Gałązka Mikołaj Kościński
author_facet	Dorota Chudoba Monika Jażdżewska Katarzyna Łudzik Sebastian Wołoszczuk Ewa Juszyńska-Gałązka Mikołaj Kościński
author_sort	Dorota Chudoba
title	Description of Release Process of Doxorubicin from Modified Carbon Nanotubes
title_short	Description of Release Process of Doxorubicin from Modified Carbon Nanotubes
title_full	Description of Release Process of Doxorubicin from Modified Carbon Nanotubes
title_fullStr	Description of Release Process of Doxorubicin from Modified Carbon Nanotubes
title_full_unstemmed	Description of Release Process of Doxorubicin from Modified Carbon Nanotubes
title_sort	description of release process of doxorubicin from modified carbon nanotubes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7574409baeea423990a1bd4710909396
work_keys_str_mv	AT dorotachudoba descriptionofreleaseprocessofdoxorubicinfrommodifiedcarbonnanotubes AT monikajazdzewska descriptionofreleaseprocessofdoxorubicinfrommodifiedcarbonnanotubes AT katarzynałudzik descriptionofreleaseprocessofdoxorubicinfrommodifiedcarbonnanotubes AT sebastianwołoszczuk descriptionofreleaseprocessofdoxorubicinfrommodifiedcarbonnanotubes AT ewajuszynskagałazka descriptionofreleaseprocessofdoxorubicinfrommodifiedcarbonnanotubes AT mikołajkoscinski descriptionofreleaseprocessofdoxorubicinfrommodifiedcarbonnanotubes
_version_	1718432124568076288

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Ejemplares similares