A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB and EGFR, which activates T cells effectively and s...

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Autores principales:	Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7575acc4586f44568954b0510de1f6d3
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spelling	oai:doaj.org-article:7575acc4586f44568954b0510de1f6d32021-12-02T15:34:29ZA tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity10.1038/s41467-018-07195-w2041-1723https://doaj.org/article/7575acc4586f44568954b0510de1f6d32018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07195-whttps://doaj.org/toc/2041-1723Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB and EGFR, which activates T cells effectively and shows negligible cytotoxicity.Marta CompteSeandean Lykke HarwoodInes G. MuñozRocio NavarroManuela ZoncaGema Perez-ChaconAinhoa Erce-LlamazaresNekane MerinoAntonio Tapia-GalisteoAngel M. CuestaKasper MikkelsenEduardo CaleirasNatalia Nuñez-PradoM. Angela AznarSimon LykkemarkJorge Martínez-TorrecuadradaIgnacio MeleroFrancisco J. BlancoJorge Bernardino de la SernaJuan M. ZapataLaura SanzLuis Alvarez-VallinaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta Compte Seandean Lykke Harwood Ines G. Muñoz Rocio Navarro Manuela Zonca Gema Perez-Chacon Ainhoa Erce-Llamazares Nekane Merino Antonio Tapia-Galisteo Angel M. Cuesta Kasper Mikkelsen Eduardo Caleiras Natalia Nuñez-Prado M. Angela Aznar Simon Lykkemark Jorge Martínez-Torrecuadrada Ignacio Melero Francisco J. Blanco Jorge Bernardino de la Serna Juan M. Zapata Laura Sanz Luis Alvarez-Vallina A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
description	Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB and EGFR, which activates T cells effectively and shows negligible cytotoxicity.
format	article
author	Marta Compte Seandean Lykke Harwood Ines G. Muñoz Rocio Navarro Manuela Zonca Gema Perez-Chacon Ainhoa Erce-Llamazares Nekane Merino Antonio Tapia-Galisteo Angel M. Cuesta Kasper Mikkelsen Eduardo Caleiras Natalia Nuñez-Prado M. Angela Aznar Simon Lykkemark Jorge Martínez-Torrecuadrada Ignacio Melero Francisco J. Blanco Jorge Bernardino de la Serna Juan M. Zapata Laura Sanz Luis Alvarez-Vallina
author_facet	Marta Compte Seandean Lykke Harwood Ines G. Muñoz Rocio Navarro Manuela Zonca Gema Perez-Chacon Ainhoa Erce-Llamazares Nekane Merino Antonio Tapia-Galisteo Angel M. Cuesta Kasper Mikkelsen Eduardo Caleiras Natalia Nuñez-Prado M. Angela Aznar Simon Lykkemark Jorge Martínez-Torrecuadrada Ignacio Melero Francisco J. Blanco Jorge Bernardino de la Serna Juan M. Zapata Laura Sanz Luis Alvarez-Vallina
author_sort	Marta Compte
title	A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
title_short	A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
title_full	A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
title_fullStr	A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
title_full_unstemmed	A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
title_sort	tumor-targeted trimeric 4-1bb-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7575acc4586f44568954b0510de1f6d3
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A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

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