High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage
Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Kang Yuan,4 Mei Zhang,1 Xiaosi Cheng,1 Min Xue,1 Liang Yu,1 Jun Lu,5,6 Chuanqing Yu1 1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, Peopl...
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Dove Medical Press
2021
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oai:doaj.org-article:757641eabd624c3eaa194dccbffca3592021-12-02T18:01:08ZHigh Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage1178-2021https://doaj.org/article/757641eabd624c3eaa194dccbffca3592021-08-01T00:00:00Zhttps://www.dovepress.com/high-uric-acid-level-predicts-early-neurological-deterioration-in-intr-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Kang Yuan,4 Mei Zhang,1 Xiaosi Cheng,1 Min Xue,1 Liang Yu,1 Jun Lu,5,6 Chuanqing Yu1 1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, People’s Republic of China; 2College of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 3Department of Cardiothoracic Surgery, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, People’s Republic of China; 4Department of Neurology, Jinling Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 5Department of Medical Laboratory, College of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 6Department of Clinical Laboratory, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun LuDepartment of Medical Laboratory, College of Medicine, Anhui University of Science and Technology, 168 Taifeng Road, Huainan, 232001, Anhui Province, People’s Republic of ChinaTel + 86- 13855453149Email cfdxlujun@126.comChuanqing YuDepartment of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, 203 Huaibin Road, Huainan, 232007, Anhui Province, People’s Republic of ChinaTel +86- 18949669880Email yuchuanqin1967@163.comObjective: Increased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END) in patients with ICH.Methods: This is a prospective observational study. Patients with ICH were enrolled from January 2017 to December 2020. END was diagnosed as the Canadian Stroke Scale (CSS) score decreased ≥ 1 points between admission and 48 hours. UA was measured at admission. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and END.Results: Of the 498 enrolled patients, 132 (26.5%) were developed with END. Patients with END had a significantly higher level of serum UA (332 vs 270 μmol/L, P < 0.001). Univariate logistic regression analysis indicated that patients with the highest quartile of UA level had an OR of 3.256 (95% CI: 1.849– 5.734, P < 0.001) for END compared with those with the lowest quartile of UA level. After adjusting for major confounders, the highest UA quartile remained as an independent predictor for END (OR = 2.282, 95% CI: 1.112– 4.685, P = 0.013).Conclusion: Higher serum UA level was independently associated with END in patients with ICH; therefore, intervention to lower UA level may be worth considering.Keywords: early neurological deterioration, intracerebral hemorrhage, uric acidGong XLu ZFeng XYuan KZhang MCheng XXue MYu LLu JYu CDove Medical Pressarticleearly neurological deteriorationintracerebral hemorrhageuric acidNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2803-2809 (2021) |
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DOAJ |
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DOAJ |
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EN |
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early neurological deterioration intracerebral hemorrhage uric acid Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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early neurological deterioration intracerebral hemorrhage uric acid Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gong X Lu Z Feng X Yuan K Zhang M Cheng X Xue M Yu L Lu J Yu C High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
| description |
Xiuqun Gong,1,* Zeyu Lu,2,* Xiwu Feng,3,* Kang Yuan,4 Mei Zhang,1 Xiaosi Cheng,1 Min Xue,1 Liang Yu,1 Jun Lu,5,6 Chuanqing Yu1 1Department of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, People’s Republic of China; 2College of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 3Department of Cardiothoracic Surgery, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, People’s Republic of China; 4Department of Neurology, Jinling Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 5Department of Medical Laboratory, College of Medicine, Anhui University of Science and Technology, Huainan, People’s Republic of China; 6Department of Clinical Laboratory, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, Huainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun LuDepartment of Medical Laboratory, College of Medicine, Anhui University of Science and Technology, 168 Taifeng Road, Huainan, 232001, Anhui Province, People’s Republic of ChinaTel + 86- 13855453149Email cfdxlujun@126.comChuanqing YuDepartment of Neurology, First Affiliated Hospital of Anhui University of Science and Technology, First People’s Hospital of Huainan, 203 Huaibin Road, Huainan, 232007, Anhui Province, People’s Republic of ChinaTel +86- 18949669880Email yuchuanqin1967@163.comObjective: Increased level of serum uric acid (UA) is often considered a risk factor for ischemic stroke. However, there are limited data on the association between UA and intracerebral hemorrhage (ICH). This study aimed to examine the connection between UA and early neurological deterioration (END) in patients with ICH.Methods: This is a prospective observational study. Patients with ICH were enrolled from January 2017 to December 2020. END was diagnosed as the Canadian Stroke Scale (CSS) score decreased ≥ 1 points between admission and 48 hours. UA was measured at admission. Multivariable logistic regression analysis was performed to explore the relationship between serum UA and END.Results: Of the 498 enrolled patients, 132 (26.5%) were developed with END. Patients with END had a significantly higher level of serum UA (332 vs 270 μmol/L, P < 0.001). Univariate logistic regression analysis indicated that patients with the highest quartile of UA level had an OR of 3.256 (95% CI: 1.849– 5.734, P < 0.001) for END compared with those with the lowest quartile of UA level. After adjusting for major confounders, the highest UA quartile remained as an independent predictor for END (OR = 2.282, 95% CI: 1.112– 4.685, P = 0.013).Conclusion: Higher serum UA level was independently associated with END in patients with ICH; therefore, intervention to lower UA level may be worth considering.Keywords: early neurological deterioration, intracerebral hemorrhage, uric acid |
| format |
article |
| author |
Gong X Lu Z Feng X Yuan K Zhang M Cheng X Xue M Yu L Lu J Yu C |
| author_facet |
Gong X Lu Z Feng X Yuan K Zhang M Cheng X Xue M Yu L Lu J Yu C |
| author_sort |
Gong X |
| title |
High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
| title_short |
High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
| title_full |
High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
| title_fullStr |
High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
| title_full_unstemmed |
High Uric Acid Level Predicts Early Neurological Deterioration in Intracerebral Hemorrhage |
| title_sort |
high uric acid level predicts early neurological deterioration in intracerebral hemorrhage |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/757641eabd624c3eaa194dccbffca359 |
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