THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE

The production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This...

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Autor principal:	O. A. Dyakovich
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2013
Materias:	vinyl chloride metabolites of vinyl chloride xenobiotics biotransformation modifying factors gene polymorphism Science Q
Acceso en línea:	https://doaj.org/article/7579a91f866a4a429d34049499f3cb9c
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spelling	oai:doaj.org-article:7579a91f866a4a429d34049499f3cb9c2021-11-23T06:14:28ZTHE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE2541-94202587-9596https://doaj.org/article/7579a91f866a4a429d34049499f3cb9c2013-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1589https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This article provides a brief review of the literature on the role of bio transformation system in functional disorders of the liver in PVC production workers. We describe the first and second phases of the biotransformation of lipophilic xenobiotics in the human body, for example, vinyl chloride. The data on gene polymorphism of enzymes involved in the metabolism of vinyl chloride (isoform of cytochrome P450 - CYP2E1, glutathione transferase GSTM1 and GSTT1) were presented in this article. The results of experimental studies of the effect of vinyl chloride on the state of the biotransformation of xenobiotics were reflected. This article examined the factors affecting the activity of the system in terms of the production of vinyl chloride exposure - age, smoking and alcohol.O. A. DyakovichScientific Сentre for Family Health and Human Reproduction Problemsarticlevinyl chloridemetabolites of vinyl chloridexenobiotics biotransformationmodifying factorsgene polymorphismScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(1), Pp 164-168 (2013)
institution	DOAJ
collection	DOAJ
language	RU
topic	vinyl chloride metabolites of vinyl chloride xenobiotics biotransformation modifying factors gene polymorphism Science Q
spellingShingle	vinyl chloride metabolites of vinyl chloride xenobiotics biotransformation modifying factors gene polymorphism Science Q O. A. Dyakovich THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
description	The production of polyvinyl chloride has currently acquired a special significance because of the widespread using of polymeric materials based on it in many industries. Vinyl chloride is a monomer of polyvinyl chloride, which is considered extremely dangerous and highly carcinogenic to humans. This article provides a brief review of the literature on the role of bio transformation system in functional disorders of the liver in PVC production workers. We describe the first and second phases of the biotransformation of lipophilic xenobiotics in the human body, for example, vinyl chloride. The data on gene polymorphism of enzymes involved in the metabolism of vinyl chloride (isoform of cytochrome P450 - CYP2E1, glutathione transferase GSTM1 and GSTT1) were presented in this article. The results of experimental studies of the effect of vinyl chloride on the state of the biotransformation of xenobiotics were reflected. This article examined the factors affecting the activity of the system in terms of the production of vinyl chloride exposure - age, smoking and alcohol.
format	article
author	O. A. Dyakovich
author_facet	O. A. Dyakovich
author_sort	O. A. Dyakovich
title	THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
title_short	THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
title_full	THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
title_fullStr	THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
title_full_unstemmed	THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE
title_sort	role of xenobiotic biotransformation in the development of liver diseases in occupational exposure to vinyl chloride
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2013
url	https://doaj.org/article/7579a91f866a4a429d34049499f3cb9c
work_keys_str_mv	AT oadyakovich theroleofxenobioticbiotransformationinthedevelopmentofliverdiseasesinoccupationalexposuretovinylchloride AT oadyakovich roleofxenobioticbiotransformationinthedevelopmentofliverdiseasesinoccupationalexposuretovinylchloride
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THE ROLE OF XENOBIOTIC BIOTRANSFORMATION IN THE DEVELOPMENT OF LIVER DISEASES IN OCCUPATIONAL EXPOSURE TO VINYL CHLORIDE

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