Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes

Wei Wu,1 Dong-Xia Li,1 Qing Wang,2 Ying Xu,2 Yun-Jing Cui2 1General Practice Wards, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China; 2Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People&rsquo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wu W, Li DX, Wang Q, Xu Y, Cui YJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	High-sensitivity cardiac troponin T Elderly inpatients Non-acute coronary syndrome Prognosis Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/757ae0809d084471aced537d3201d98f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:757ae0809d084471aced537d3201d98f
record_format	dspace
spelling	oai:doaj.org-article:757ae0809d084471aced537d3201d98f2021-12-02T07:41:20ZRelationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes1178-1998https://doaj.org/article/757ae0809d084471aced537d3201d98f2018-06-01T00:00:00Zhttps://www.dovepress.com/relationship-between-high-sensitivity-cardiac-troponin-t-and-the-progn-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Wei Wu,1 Dong-Xia Li,1 Qing Wang,2 Ying Xu,2 Yun-Jing Cui2 1General Practice Wards, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China; 2Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated. Materials and methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study. The patients were grouped according to the tertiles of hs-cTnT levels. Biochemical markers, hs-cTnT, and amino-terminal pro-brain natriuretic peptide were measured. The median follow-up period was 47 months, and all-cause deaths of the patients were observed. Results: A total of 722 patients, including 473 males and 249 females, aged 65–98 (82.43±5.98) years were enrolled in the study. The level of hs-cTnT was found to be higher in males, and increased with age and comorbidities (P<0.01). Compared with low-level group, NT-proBNP level of patients in high-level group was higher, while hemoglobin (Hb), estimated glomerular filtration rate (eGFR), and left ventricular ejection fraction (LVEF) levels were lower (P<0.001). The mortality rate increased significantly with increased hs-cTnT levels (P<0.001). The total number of deaths was 136 (18.8%), and of these, 108 (79.4%) were noncardiac deaths. Risk of all-cause deaths in the highest hs-cTnT level group was 7.3 times higher than that of the lowest hs-cTnT level group (95% CI: 4.29–12.51, P<0.001). After adjusting for gender, age, comorbidities, NT-proBNP, Hb, eGFR, and LVEF, hs-cTnT level still affected the patient’s survival time (HR: 3.01, 95% CI: 1.67–5.43, P<0.001). Conclusion: These findings suggest that low-level hs-cTnT was increased in elderly inpatients without ACS. They further highlight that baseline hs-cTnT level was associated with increased risk of all-cause deaths among patients after their discharge, and most deaths were from non-cardiovascular diseases. Keywords: high-sensitivity cardiac troponin T, elderly inpatients, non-acute coronary syndrome, prognosisWu WLi DXWang QXu YCui YJDove Medical PressarticleHigh-sensitivity cardiac troponin TElderly inpatientsNon-acute coronary syndromePrognosisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1091-1098 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	High-sensitivity cardiac troponin T Elderly inpatients Non-acute coronary syndrome Prognosis Geriatrics RC952-954.6
spellingShingle	High-sensitivity cardiac troponin T Elderly inpatients Non-acute coronary syndrome Prognosis Geriatrics RC952-954.6 Wu W Li DX Wang Q Xu Y Cui YJ Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes
description	Wei Wu,1 Dong-Xia Li,1 Qing Wang,2 Ying Xu,2 Yun-Jing Cui2 1General Practice Wards, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China; 2Department of Geriatrics, Fuxing Hospital Affiliated to Capital Medical University, Beijing, People’s Republic of China Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated. Materials and methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study. The patients were grouped according to the tertiles of hs-cTnT levels. Biochemical markers, hs-cTnT, and amino-terminal pro-brain natriuretic peptide were measured. The median follow-up period was 47 months, and all-cause deaths of the patients were observed. Results: A total of 722 patients, including 473 males and 249 females, aged 65–98 (82.43±5.98) years were enrolled in the study. The level of hs-cTnT was found to be higher in males, and increased with age and comorbidities (P<0.01). Compared with low-level group, NT-proBNP level of patients in high-level group was higher, while hemoglobin (Hb), estimated glomerular filtration rate (eGFR), and left ventricular ejection fraction (LVEF) levels were lower (P<0.001). The mortality rate increased significantly with increased hs-cTnT levels (P<0.001). The total number of deaths was 136 (18.8%), and of these, 108 (79.4%) were noncardiac deaths. Risk of all-cause deaths in the highest hs-cTnT level group was 7.3 times higher than that of the lowest hs-cTnT level group (95% CI: 4.29–12.51, P<0.001). After adjusting for gender, age, comorbidities, NT-proBNP, Hb, eGFR, and LVEF, hs-cTnT level still affected the patient’s survival time (HR: 3.01, 95% CI: 1.67–5.43, P<0.001). Conclusion: These findings suggest that low-level hs-cTnT was increased in elderly inpatients without ACS. They further highlight that baseline hs-cTnT level was associated with increased risk of all-cause deaths among patients after their discharge, and most deaths were from non-cardiovascular diseases. Keywords: high-sensitivity cardiac troponin T, elderly inpatients, non-acute coronary syndrome, prognosis
format	article
author	Wu W Li DX Wang Q Xu Y Cui YJ
author_facet	Wu W Li DX Wang Q Xu Y Cui YJ
author_sort	Wu W
title	Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes
title_short	Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes
title_full	Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes
title_fullStr	Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes
title_full_unstemmed	Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes
title_sort	relationship between high-sensitivity cardiac troponin t and the prognosis of elderly inpatients with non-acute coronary syndromes
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/757ae0809d084471aced537d3201d98f
work_keys_str_mv	AT wuw relationshipbetweenhighsensitivitycardiactroponintandtheprognosisofelderlyinpatientswithnonacutecoronarysyndromes AT lidx relationshipbetweenhighsensitivitycardiactroponintandtheprognosisofelderlyinpatientswithnonacutecoronarysyndromes AT wangq relationshipbetweenhighsensitivitycardiactroponintandtheprognosisofelderlyinpatientswithnonacutecoronarysyndromes AT xuy relationshipbetweenhighsensitivitycardiactroponintandtheprognosisofelderlyinpatientswithnonacutecoronarysyndromes AT cuiyj relationshipbetweenhighsensitivitycardiactroponintandtheprognosisofelderlyinpatientswithnonacutecoronarysyndromes
_version_	1718399229816209408

Relationship between high-sensitivity cardiac troponin T and the prognosis of elderly inpatients with non-acute coronary syndromes

Ejemplares similares